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REN Lixia, WANG Bo. Preparation and characterization of carvedilol solid dispersions using hollow mesoporous silica nanoparticles[J]. Journal of China Pharmaceutical University, 2014, 45(1): 59-64. DOI: 10.11665/j.issn.1000-5048.20140110
Citation: REN Lixia, WANG Bo. Preparation and characterization of carvedilol solid dispersions using hollow mesoporous silica nanoparticles[J]. Journal of China Pharmaceutical University, 2014, 45(1): 59-64. DOI: 10.11665/j.issn.1000-5048.20140110
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Preparation and characterization of carvedilol solid dispersions using hollow mesoporous silica nanoparticles

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    • Abstract
  • The aims of this study were to prepare hollow mesoporous silica nanoparticles(HMSNs)and to evaluate its effect on drug loading and dissolution. Carvedilol, a sparely water-insoluble drug has been selected as the model drug. Carvedilol solid dispersions were prepared by solvent evaporation method using HMSNs as the drug carrier and absolute alcohol as solvent. The solid dispersions were characterized by transmission electron microscope(TEM), scanning electron microscope(SEM), N2 adsorption-desorption, FT-IR spectroscopy, differential scanning calorimeter(DSC)and X-ray diffraction(XRD). In vitro drug release behavior and the short-term stability were also investigated. The results showed that drugs were highly dispersed into the hollow cores and mesopores of HMSNs in amorphous form. In addition, the results of in vitro dissolution testing showed that the accumulated dissolutions of carvedilol solid dispersions could reach 95% within 60 min, when the mass ratio of the drug and the carrier was 1 ∶5. 3-Month accelerated stability testing obesrved no significant changes to drug dissolution and content presented in the solid dispersions. The significant improvement of drug dissolution demonstrated that HMSNs could provide good reservoirs or carriers for sparely water-insoluble drugs, and have high potential in future applications for oral delivery of therapeutic drugs.
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    • References (17)
  • [1]
    Xu W,Riikonen J,Lehto VP.Mesoporous systems for poorly soluble drugs[J].Int J Pharm,2013,453(1):181-197.
    [2]
    Zhang Y,Zhi Z,Jiang T,et al.Spherical mesoporous silica nanoparticles for loading and release of the poorly water-soluble drug telmisartan[J].J Control Release,2010,145(3):257-263.
    [3]
    Planinšek O,Kovai B,Vreer F.Carvedilol dissolution improvement by preparation of solid dispersions with porous silica[J].Int J Pharm,2011,406(1/2):41-48.
    [4]
    Liu T,Li L,Teng X,et al.Single and repeated dose toxicity of mesoporous hollow silica nanoparticles in intravenously exposed mice[J].Biomaterials,2011,32(6):1 657-1 668.
    [5]
    Chen B,Quan GL,Wang ZH,et al.Hollow mesoporous silicas as a drug solution delivery system for insoluble drugs[J].Powder Technol,2013,240:48-53.
    [6]
    Zhu Y,Fang Y,Borchardt L,et al.PEGylated hollow mesoporous silica nanoparticles as potential drug delivery vehicles[J].Micropor Mesopor Mater,2011,141(1):199-206.
    [7]
    Wang YZ,Sun LZ,Song AH,et al.Synthesis of mesoporous silica nanoparticle and the effect on drug loading and dissolution[J].J Shenyang Pharm Univ(沈阳药科大学学报),2012,29(4):258-263.
    [8]
    Liu CY,Hu JH,Yang D,et al.Preparation of multi-responsive mesoporous silica microspheres and its application in controlled drug release[J].Acta Chim Sin(化学学报),2009,67(8):843-849.
    [9]
    Liu X,Kaminski MD,Guan Y,et al.Preparation and characterization of hydrophobic superparamagnetic magnetite gel[J].J Magn Magn Mater,2006,306(2):248-253
    [10]
    Yang K,Peng HB,Wen YH,et al.Influence of ethanol on the physically absorpted layer of bilayer oleic acid-coated structure[J].J Funct Mater Devices,2010,16(4):363-368.
    [11]
    Kruk M,Jaroniec M,Ryoo R,et al.Characterization of high-quality MCM-48 and SBA-1 mesoporous silicas[J].Chem Mater,1999,11(9):2 568-2 572.
    [12]
    Jiao Y,Guo J,Shen S,et al.Synthesis of discrete and dispersible hollow mesoporous silica nanoparticles with tailored shell thickness for controlled drug release[J].J Mater Chem,2012,22(34):17 636-17 643.
    [13]
    Quan GL,Chen B,Wang ZH,et al.Improving the dissolution rate of poorly water-soluble resveratrol by the ordered mesoporous silica[J].Acta Pharm Sin(药学学报),2012,47(2):239-243.
    [14]
    Sharma A,Jain CP.Preparation and characterization of solid dispersions of carvedilol with PVP K30[J].Res Pharm Sci,2010,5(1):49.
    [15]
    Hu Y,Zhi Z,Zhao Q,et al.3D cubic mesoporous silica microsphere as a carrier for poorly soluble drug carvedilol[J].Micropor Mesopor Mater,2012,147(1):94-101.
    [16]
    Kovai B,Vreer F,Planinšek O.Solid dispersions of carvedilol with porous silica[J].Chem Pharm Bull,2011,59(4):427-433.
    [17]
    Tang Y,Ke X.Advances of mesoporous silica nanoparticles as drug delivery system[J].J China Pharm Univ(中国药科大学学报),2012,43(6):567-572.
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