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LI Xi, HE Hua, LIU Yao, WANG Shijun, WANG Haidong, LIU Xiaoquan. Effect of salvianolic acid A on uric acid metabolism in acute myocardial infarction rats[J]. Journal of China Pharmaceutical University, 2014, 45(3): 335-340. DOI: 10.11665/j.issn.1000-5048.20140315
Citation: LI Xi, HE Hua, LIU Yao, WANG Shijun, WANG Haidong, LIU Xiaoquan. Effect of salvianolic acid A on uric acid metabolism in acute myocardial infarction rats[J]. Journal of China Pharmaceutical University, 2014, 45(3): 335-340. DOI: 10.11665/j.issn.1000-5048.20140315
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Effect of salvianolic acid A on uric acid metabolism in acute myocardial infarction rats

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    • Abstract
  • The aim of this study was to investigate the effect of salvianolic acid A(SalA)on uric acid metabolism in acute myocardial infarction(AMI)rats. Rats were randomly divided into Sham, AMI and SalA groups. The AMI model underwent coronary artery ligation and the survival AMI rats received a single intravenous dose of 5 mg/kg of SalA and normal saline. The uric acid plasma and myocardial concentrations, myocardial adenine nucleotides(AMP, ADP and ATP), inosine, xanthine, hypoxanthine were determined by HPLC and plasma xanthine oxidase activity was measured spectrophotometrically using commercial diagnostic kits. Myocardial infarct rate was measured by TTC dying method. After AMI, myocardial ATP depleted, the infarct rate increased and purine compounds released from necrotic cells, resulting in the increased uric acid substrate in plasma. Furthermore, the xanthine oxidase activity in plasma was increased, so the elevated substrate and increased xanthine oxidase activity resulted in elevated plasma uric acid levels. SalA increased high-energy phosphate compounds and inosine levels, reduced myocardial infarct rate, so less purine compound released to plasma. SalA also inhibited xanthine oxidase activity in plasma. Therefore, plasma uric acid was declined. The results suggested that SalA could exhibit cardiovascular protective effects by regulating of uric acid synthesis in AMI rats.
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  • [1]
    Chan D,Ng LL.Biomarkers in acute myocardial infarction[J].BMC Med,2010,8(1):34.
    [2]
    Kanbay M,Segal M,Afsar B,et al.The role of uric acid in the pathogenesis of human cardiovascular disease[J].Heart,2013,99(11):759-766.
    [3]
    Lee BE,Toledo AH,Anaya-Prado R,et al.Allopurinol,xanthine oxidase,and cardiac ischemia[J].J Investig Med,2009,57(8):902-909.
    [4]
    de Oliveira EP,Burini RC.High plasma uric acid concentration:causes and consequences[J].Diabetol Metab Syndr,2012,4(1):12.
    [5]
    Lazaros G,Tsiachris D,Aznaouridis K,et al.Uric acid in-hospital changes predict mortality in patients with acute myocardial infarction[J].Nutr Metab Cardiovasc Dis,2013,23(12):1 202-1 209.
    [6]
    Sedaghat S,Hoorn EJ,van Rooij FJ,et al.Serum uric acid and chronic kidney disease:the role of hypertension[J].PloS One,2013,8(11):e76827.
    [7]
    Xu Y,Zhu J,Gao L,et al.Hyperuricemia as an independent predictor of vascular complications and mortality in type 2 diabetes patients:a meta-analysis[J].PloS one,2013,8(10):e78206.
    [8]
    Levantesi G,Marfisi RM,Franzosi MG,et al.Uric acid:a cardiovascular risk factor in patients with recent myocardial infarction[J].Int J Cardiol,2013,167(1):262-269.
    [9]
    Fan H,Fu F,Yang M,et al.Antiplatelet and antithrombotic activities of salvianolic acid A[J].Thromb Res,2010,126(1):e17-e22.
    [10]
    Wang S,Tian S,Yang F,et al.Cardioprotective effect of salvianolic acid A on isoproterenol-induced myocardial infarction in rats[J].Eur J Pharmacol,2009,615(1):125-132.
    [11]
    Sun L,Zhao R,Zhang L,et al.Salvianolic acid A inhibits PDGF-BB induced vascular smooth muscle cell migration and proliferation while does not constrain endothelial cell proliferation and nitric oxide biosynthesis[J].Molecules,2012,17(3):3 333-3 347.
    [12]
    Yang L,Li D,Zhang Y,et al.Salvianolic acid A inhibits angiotensin II-induced proliferation of human umbilical vein endothelial cells by attenuating the production of ROS[J].Acta Pharmacol Sin,2011,33(1):41-48.
    [13]
    Zhang L,Chang BB,Chao WW,et al.Effect of danshensu on myocardial energy metabolism in isolated ischemia reperfusion rat hearts[J].J China Pharm Univ(中国药科大学学报),2010,41(3):278-282.
    [14]
    Huang LH,Chen YC,Cheng Y,et al.Effect of content variation of water-soluble components on myocardial energy metabolism in isolated ischemia-reperfusion rat hearts[J].J China Pharm Univ(中国药科大学学报),2011,42(4):348-353.
    [15]
    Ma C,Huo SF,Cao YG,et al.Regulation of Danshen injection on cardiac energy metabolism in rats[J].J China Pharm Univ(中国药科大学学报),2009,40(2):147-151.
    [16]
    Carrasco-Pozo C,Gotteland M,Speisky H.Apple peel polyphenol extract protects against indomethacin-induced damage in Caco-2 cells by preventing mitochondrial complex I inhibition[J].J Agric Food Chem,2011,59(21):11 501-11 508.
    [17]
    Bagul PK,Middela H,Matapally S,et al.Attenuation of insulin resistance,metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats[J].Parmacol Res,2012,66(3):260-268.
    [18]
    Chen YC,Cao WW,Cao Y,et al.Using neural networks to determine the contribution of danshensu to its multiple cardiovascular activities in acute myocardial infarction rats[J].J Ethnopharmacol,2011,138(1):126-134?监ぢ????戱??㈠??扬???ラ??????????????oga P,et al.Development of an HPLC method for determination of metabolic compounds in myocardial tissue[J].J Pharm Biomed Anal,2004,35(3):647-653.
    [19]
    Akula KK,Kaur M,Bishnoi M,et al.Development and validation of an RP-HPLC method for the estimation of adenosine and related purines in brain tissues of rats[J].J Sep Sci,2008,31(18):3 139-3 147.
    [20]
    Coolen EJ,Arts IC,Swennen EL,et al.Simultaneous determination of adenosine triphosphate and its metabolites in human whole blood by RP-HPLC and UV-detection[J].J Chromatogr B Analyt Technol Biomed Life Sci,2008,864(1/2):43-51.
    [21]
    Wang J,Jiang Z,Ji J,et al.Evaluation of hepatotoxicity and cholestasis in rats treated with EtOH extract of Fructus Psoraleae[J].J Ethnopharmacol,2012,144(1):73-81.
    [22]
    Al-Shamiri SA,Hasan NA,Frankul WM,et al.Purines and oxypurines in myocardial ischemia[J].Saudi Med J,2009,30(2):257-266.
    [23]
    Lewis GD,Wei R,Liu E,et al.Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury[J].J Clin Invest,2008,118(10):3 503-3 512.
    [24]
    Ponce A,Blanco S,Molina A,et al.Study of the action of flavonoids on xanthine-oxidase by molecular topology[J].J Chem Inf Comput Sci,2000,40(4):1 039-1 045.
    [25]
    Sezai A,Soma M,Nakata K,et al.Comparison of febuxostat and allopurinol for hyperuricemia in cardiac surgery patients(NU-FLASH Trial)[J].Circ J,2013,77(8):2 043-2 049.
    [26]
    Halliwell B.Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies[J]?Arch Biochem Biophys,2008,476(2):107-112.
    [27]
    He H,Wang S,Li X,et al.A novel metabolic balance model for describing the metabolic disruption of and interactions between cardiovascular-related markers during acute myocardial infarction[J].Metabolism
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