Preparation and characterization of oligomeric hyaluronic acid-ketal as a tumour CD44 receptor and pH-sensitive targeting carrier

LIAN Shengnan; SUN Jingfang; SUN Kaoxiang; LIU Wanhui; CHEN Daquan

doi:10.11665/j.issn.1000-5048.20140506

Journal of China Pharmaceutical University > 2014 > 45(5): 540-543. > DOI: 10.11665/j.issn.1000-5048.20140506

LIAN Shengnan, SUN Jingfang, SUN Kaoxiang, LIU Wanhui, CHEN Daquan. Preparation and characterization of oligomeric hyaluronic acid-ketal as a tumour CD44 receptor and pH-sensitive targeting carrier[J]. Journal of China Pharmaceutical University, 2014, 45(5): 540-543. DOI: 10.11665/j.issn.1000-5048.20140506

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Preparation and characterization of oligomeric hyaluronic acid-ketal as a tumour CD44 receptor and pH-sensitive targeting carrier

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Oligomeric hyaluronic acid(oHA)and ketal was linked by histidine to form a novel oHA-ketal(oHM)carrier with targeting capacity to CD44 receptor and pH sensitivity. The chemical structure of oHM was characterized by ¹H NMR and ESI-MS. Some properties, including the formation of micelles, morphology and pH-sensitivity were studied. The oHM can form micelles by self-assembly. The micelles were spherical shape with the diameter about 100 nm, and they also showed some pH-sensitivity. Therefore, oHM could be a potential pH-sensitive tumor targeting carrier to CD44 receptor.
- oligomeric hyaluronic acid,
- ketal,
- preparation,
- characterization,
- tumour targeting carrier

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Preparation and characterization of oligomeric hyaluronic acid-ketal as a tumour CD44 receptor and pH-sensitive targeting carrier

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