• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
PAN Ronghua, YANG Chen. Preparation and in vitro release of Yangshen-paidu sustained-release tablet[J]. Journal of China Pharmaceutical University, 2014, 45(6): 684-688. DOI: 10.11665/j.issn.1000-5048.20140612
Citation: PAN Ronghua, YANG Chen. Preparation and in vitro release of Yangshen-paidu sustained-release tablet[J]. Journal of China Pharmaceutical University, 2014, 45(6): 684-688. DOI: 10.11665/j.issn.1000-5048.20140612

Preparation and in vitro release of Yangshen-paidu sustained-release tablet

More Information
  • To study the preparation process of the Yangshen-paidu sustained-release tablet, the preparation parameters were investigated by the single factor design method. The formulation was optimized to be 70% of extraction, 25% of HPMC, 4% of lactose, and 1% of magnesium stearate. The release rate of salvianolic acid B, tanshinone IIA, the total Anthraquinone of Radix et Rhizoma Rhei, Astragaloside A from the sustained-release tablet in vitro were measured according to Chinese Pharmacopeia(CP)2010 using Dissolution Testing Apparatus 1(basket method). The similarity factor was used to compare cumulative release curves. The cumulative curve of drug release data were fitted to zero order, first-order and Higuchi models to ascertain the kinetic modeling of drug release. The release mechanism was ascertained using Peppas equation. The similarity factors of the cumulative release curve of four ingredients mutually compared were all over 80, indicating that the release of four ingredients was similar. The cumulative release rate of four ingredients all fitted Higuchi models. The value of slopes of Peppas models of four ingredients was all more than 0. 45, indicating that the drug released by concurrent action of diffusion and matrix erode(non-fickian diffusion). This preparation technology of Yangshen-paidu sustained-release tablet is rational and practicable.
  • [1]
    Pan RH,Rui GH.A drug for nourish the kidneys and elimination of toxicant:CN,ZL200710191384.X[P].2010-06-02[2014-07-04] .
    [2]
    Cui FD.Pharmaceutics(药剂学)[M].7th ed.Beijing:People′s Medical Publishing House,2011:422-426.
    [3]
    Cai YQ,Chen J,Xie JF,et al.Evaluation of balanced release of complex components of Chuanping sustained tablets based on fingerprint[J].China J Chin Mater Med(中国中药杂志),2013,38(9):1 360-1 365.
    [4]
    He Y, Zhang XX, Pan WS. Study on breviscapin hydrophilic matrics sustained release tablets[J].China Pharm J(中国药学杂志),2006,41(2):119-122.
    [5]
    Zhu SS, Yuan XJ, Li YX. Study of balanced release of slow-release TCM compound preparations for treatment of coronary heart disease[J].Mod Tradit Chin Med Mater Med-World Sci Tech(世界科学技术-中医药现代化),2006,8(1):44-47.
  • Related Articles

    [1]WANG Wendie, ZHOU Jiyuan, TANG Lidan, YIN Tingjie. Preparation and characterization of dasatinib albumin micelles[J]. Journal of China Pharmaceutical University, 2022, 53(3): 286-292. DOI: 10.11665/j.issn.1000-5048.20220305
    [2]ZHANG Zhan, FENG Yan, LI Qian, CUI Li. Characterization of a UDP-glucose 4-epimerase from Acinetobacter Baumannii[J]. Journal of China Pharmaceutical University, 2021, 52(6): 742-750. DOI: 10.11665/j.issn.1000-5048.20210613
    [3]GUO Yahui, LU Peng, WANG Yubin, ZHANG Huibin. Progress in the researches for antitumor NEDD8 activating enzyme inhibitors[J]. Journal of China Pharmaceutical University, 2017, 48(6): 646-653. DOI: 10.11665/j.issn.1000-5048.20170603
    [4]SONG Yiting, LIAO Jiao, QI Xuan, GAO Yuan, ZHANG Jianjun. Physicochemical characterization of co-amorphous repaglinide-saccharin[J]. Journal of China Pharmaceutical University, 2013, 44(5): 427-431. DOI: 10.11665/j.issn.1000-5048.20130508
    [5]WANG Jing, GAN Li, GAN Yong, LIU Jianping. Preparation and characterization of hyaluronic acid-modified dexamethasone core-shell liponanoparticles[J]. Journal of China Pharmaceutical University, 2013, 44(2): 117-123. DOI: 10.11665/j.issn.1000-5048.20130204
    [6]Characterization of N-terminal PEGylated Endostar[J]. Journal of China Pharmaceutical University, 2010, 41(5): 476-480.
    [7]Preparation and Characterization of Novel Galactosylated Chitosan[J]. Journal of China Pharmaceutical University, 2003, (5): 1-4.
    [8]Purification and Characterization of Potent Fibrinolytic Enzyme from Earthworm[J]. Journal of China Pharmaceutical University, 1997, (6): 48-51.
    [9]Pharmacokinetic Studies of Nevin Fibrinolytic Enzyme[J]. Journal of China Pharmaceutical University, 1997, (2): 107-110.
    [10]A New Enzyme Amplification System and Its Application[J]. Journal of China Pharmaceutical University, 1995, (1): 55+53-55.

Catalog

    Article views (1109) PDF downloads (1051) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return