Effects of colchicine on cholestatic liver injury in rats induced by bile duct ligation

WANG Tao; ZHOU Zhixing; LIU Wei; JIANG Zhenzhou; ZHAO Guolin; SHANG Jing; ZHANG Luyong

doi:10.11665/j.issn.1000-5048.20140618

Journal of China Pharmaceutical University > 2014 > 45(6): 715-719. > DOI: 10.11665/j.issn.1000-5048.20140618

WANG Tao, ZHOU Zhixing, LIU Wei, JIANG Zhenzhou, ZHAO Guolin, SHANG Jing, ZHANG Luyong. Effects of colchicine on cholestatic liver injury in rats induced by bile duct ligation[J]. Journal of China Pharmaceutical University, 2014, 45(6): 715-719. DOI: 10.11665/j.issn.1000-5048.20140618

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Effects of colchicine on cholestatic liver injury in rats induced by bile duct ligation

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To investigate the effects of colchicine on the cholestasis in rats induced by bile duct ligation(BDL), colchicine(0. 12 and 0. 24 mg/kg)was administered intragastrically for 7 consecutive days after ligation of common bile duct. The effect of colchicines on the liver injury was evaluated by serum biochemistry(ALT, AST, ALP, γ-GTP, TBIL, DBIL, ALB and TBA), liver myeloperoxidase(MPO)activity as well as histological examination. Both doses of colchicine significantly decreased serum ALP, γ-GTP and TBA levels, inhibited liver MPO activity and alleviate liver histological changes, such as inflammatory cell infiltration and interlobular bile duct hyperplasia. Data suggested that lower dose of colchicines(≤0. 24 mg/kg)exerted protection of bile duct injury induced by BDL in rats involving primary mechanism on inhibiting activation and infiltration of inflammatory cells.
- colchicine,
- bile duct ligation,
- cholestasis,
- neutrophil,
- inflammation

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