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ZHANG Jie, CHI Huibo, CHENG Yanju, CAO Feng. Ophthalmic solution of thiolated chitosan-pirenoxine sodium-layered double hydroxides hybrid nanocomposites[J]. Journal of China Pharmaceutical University, 2015, 46(2): 201-208. DOI: 10.11665/j.issn.1000-5048.20150211
Citation: ZHANG Jie, CHI Huibo, CHENG Yanju, CAO Feng. Ophthalmic solution of thiolated chitosan-pirenoxine sodium-layered double hydroxides hybrid nanocomposites[J]. Journal of China Pharmaceutical University, 2015, 46(2): 201-208. DOI: 10.11665/j.issn.1000-5048.20150211
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Ophthalmic solution of thiolated chitosan-pirenoxine sodium-layered double hydroxides hybrid nanocomposites

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  • Ophthalmic solution of organic-inorganic layered double hydroxides hybrid nanocomposites based on layered double hydroxides(LDH)intercalated with pirenoxine sodium(PRN)and chitosan-glutathione(CG)was prepared, characterized and evaluated using rabbit precorneal retention. Mg-Al-PRN-LDH, Zn-Al-PRN-LDH and CG-PRN-LDH were synthesized by co-precipitation. The nanocomposites were characterized by laser particle sizer, powder X-ray diffraction(X-RD), fourier transform infrared spectra(FTIR)and transmission electron micrographs(TEM). The release of PRN from Mg-Al-PRN-LDH, Zn-Al-PRN-LDH, and CG-PRN-LDH nanocomposites and API in artificial tear was compared. Based on in vivo precorneal retention studies, PRN-LDH and CG-PRN-LDH nanocomposite dispersions showed significantly higher AUC(3. 72-, 7. 59-folds)and MRT(2. 18-, 2. 60-folds)than that of the commercial eye drops group. Organic-inorganic layered double hydroxides hybrid nanocomposites CG-PRN-LDH dispersions could remarkably improve precorneal retention of PRN.
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  • [1]
    Allmann R.The crystal structure of pyroaurite[J].Acta Crystallogr B,1986(24):972-977.
    [2]
    Rives V,Arco MD,Martn C.Layered double hydroxides as drug carriers and for controlled non-steroid:a review[J].J Control Release,2013,168(1/2):28-39.
    [3]
    Chakrabortia M,Jacksona JK,Plackettb D,et al.Drug intercalation in layered double hydroxide clay:application in the development of a nanocomposite film for guided tissue regeneration[J].Int J Pharm,2011,416(2):305-313.
    [4]
    Zhang XQ,Zeng MG,Li SP,et al,Methotrexate intercalated layered double hydroxides with differentparticle sizes:structural study and controlled release properties[J].Colloid Surf B:Biointerfaces,2014,117(1):98-106.
    [5]
    Berber MR.,Hafez IH,Minagawa K,et al.Nanocomposite formulation system of lipid-regulating drugs based on layered double hydroxide:synthesis,characterization and drug release properties[J].Pharm Res,2010,27(11):2394-2401.
    [6]
    Rives V,Arco MD,Martin C.Intercalation of drugs in layered double hydroxides and their controlled release[J].App Clay Sci,2014(89):239-269.
    [7]
    Kafedjiiski K, Foger F, Werle M, et al. Synthesis and in vitro evaluation of a novel chitosan-glutathione conjugate[J].Pharm Res,2005,22(9):1480-1488.
    [8]
    Ylenia Z,Francesca F,Angela F,et al.Mucoadhesive nanoparticles made of thiolated quaternary chitosan crosslinked with hyaluronan[J].Carbohydr Polym,2013,92(1):33-39.
    [9]
    Miriam C,Salvatore S,Marcella C.Pirenoxine prevents oxidative effects of argon fluoride excimer laser irradiation in rabbit corneas:biochemical,histological and cytofluorimetric evaluations[J].J Photoch Photobiol B,2005,78(1):35-42.
    [10]
    Chennamaneni SR,Mamalis C,Archer B,et al.Development of a novel bioerodible dexamethasone implant for uveitis and postoperative cataract inflammation[J].J Control Release,2013,167(1):53-59.
    [11]
    Cao F, Wang YJ, Ping QN, et al. Zn-Al-NO3-layered double hydroxides with intercalated diclofenac for ocular delivery[J].Int J Pharm,2011,404(1/2):250-256.
    [12]
    Jin XF,Xu Y,Shen J,et al.Chitosan-glutathione conjugate-coated poly(butyl cyanoacrylate)nanoparticles:promising carriers for oral thymopentin delivery[J].Carbohydr Polym,2011,86(1):51-57.
    [13]
    Wang YJ,Cao F,Ping QN.Preparation and characterization of diclofenac sodium layered double hydroxide nanohybrids[J].J China Pharm Univ(中国药科大学学报),2009,40(4):321-326.
    [14]
    Yong L,Wang A,Ping X,et al.Structural and spectroscopic study of tripeptide/layered double hydroxide hybrids[J].J Colloid Interf Sci,2013(394):564-572.
    [15]
    Chinese Pharmacopoeia Commission.Drug Standard of Ministry of Public Health of the People′s Republic of China:Part 2(中华人民共和国卫生部药品标准:二部)[S].Beijing:Chemical Industry Press,1995:46-48.
    [16]
    Kong CX,Zhang Q,Liu YN,et al.Determination of Pirenoxine sodium and its related substances by HPLC[J].China Pharm(中国药师),2013,16(1):66-69.
    [17]
    Zhu HG, Tang PG, Feng YJ. Intercalation of IR absorber into layered double hydroxides:preparation,thermal stability and selective IR absorption[J].Mater Res Bull,2012,47(3):532-536.
    [18]
    Kuk WK,Huh YD.Preferential intercalation of isomers of anthraquinone sulfonate ions into layered double hydroxides[J].J Mater Chem,1997,7(9):1933-1936.
    [19]
    Amrite AC,Eeelhauser HF,Singh SR,et al.Effect of circulation on the disposition and ocular tissue distribution of nanoparticles after periocular administration[J].Mol Vis,2008,14(29):150-160.
    [20]
    Li Y,Ni ZM,Xu Q,et al.Molecular dynamics simulation of histidine intercalated Zn/Al hydrotalcite and releasen course[J].J Chin Ceram Soc(硅酸盐学报),2011,1(39):63-68.
    [21]
    Qin ZG,Cao F,Ping QN,et al.Layered double hydroxides and their applications in drug delivery systems[J].Prog Pharm Sci(药学进展),2013,37(12):615-622.
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