Physicochemical characteristics of coamorphous simvastatin-gliclazide

CHEN Juan; GUO Huihui; ZHANG Jianjun; GAO Yuan

doi:10.11665/j.issn.1000-5048.20150307

Journal of China Pharmaceutical University > 2015 > 46(3): 301-308. > DOI: 10.11665/j.issn.1000-5048.20150307

CHEN Juan, GUO Huihui, ZHANG Jianjun, GAO Yuan. Physicochemical characteristics of coamorphous simvastatin-gliclazide[J]. Journal of China Pharmaceutical University, 2015, 46(3): 301-308. DOI: 10.11665/j.issn.1000-5048.20150307

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Physicochemical characteristics of coamorphous simvastatin-gliclazide

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Abstract

In this study, coamorphous simvastatin-gliclazide was prepared and characterized. Its single-phase amorphous nature was demonstrated. The hydrogen bond between the O-H group of simvastatin and sulfonylurea C=O group of gliclazide was revealed to be the trigger for the amorphization of gliclazide, which is difficult to form an amorphous state in other methods. Coamorphous simvastatin-gliclazide can significantly enhance the solubility and dissolution of gliclazide, without obvious effect on simvastatin. Compared with amorphous simvastatin, coamorphous simvastatin-gliclazide showed improved physical stability in the cunrent study.
- simvastatin,
- gliclazide,
- amorphous,
- coamorphous,
- dissolution,
- stability

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