Preparation and <i>in vitro </i>properties of paclitaxel-loaded mesoporous silica nanoparticle

ZHANG Xue; SU Zhigui; XUE Lingjing; ZHANG Can

doi:10.11665/j.issn.1000-5048.20150603

Journal of China Pharmaceutical University > 2015 > 46(6): 653-658. > DOI: 10.11665/j.issn.1000-5048.20150603

ZHANG Xue, SU Zhigui, XUE Lingjing, ZHANG Can. Preparation and in vitro properties of paclitaxel-loaded mesoporous silica nanoparticle[J]. Journal of China Pharmaceutical University, 2015, 46(6): 653-658. DOI: 10.11665/j.issn.1000-5048.20150603

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Preparation and in vitro properties of paclitaxel-loaded mesoporous silica nanoparticle

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Mesoporous silica nanoparticle as drug carrier has become the new research focus in the field of nano-drug delivery system in recent years. In this study, paclitaxel-loaded msesoporous silica nanoparticle(PTX@MSN)was manufactured by the solvent adsorption. In vitro studies revealed that PTX@MSN was well dispersed in aqueous medium with particle size of 250 nm, the potential of -(8. 01±1. 81)mV and drug loading efficiency of(23. 76±1. 14)%. PTX@MSN showed the sustained-release characteristics with the cumulative PTX of release(23. 62±2. 15)% at 24 h. In additions, the cytotoxicity investigation indicated that blank MSNs were biocompatible while PTX@MSN group showed improved in vitro anti-tumor activity against HepG2 cell when compared with Taxol group. In conclusion, MSN is a promising platform to build drug delivery systems for tumor therapy.
- mesoporous silica nanoparticles,
- paclitaxel,
- in vitro drug release,
- anti-tumor activity

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Preparation and in vitro properties of paclitaxel-loaded mesoporous silica nanoparticle

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