LUO Yan, GU Jinhua, LUO Zhiteng, WU Jie, YE Lianbao. Synthesis of the related substances of deferasirox[J]. Journal of China Pharmaceutical University, 2016, 47(3): 288-290. DOI: 10.11665/j.issn.1000-5048.20160306
Citation:
LUO Yan, GU Jinhua, LUO Zhiteng, WU Jie, YE Lianbao. Synthesis of the related substances of deferasirox[J]. Journal of China Pharmaceutical University, 2016, 47(3): 288-290. DOI: 10.11665/j.issn.1000-5048.20160306
LUO Yan, GU Jinhua, LUO Zhiteng, WU Jie, YE Lianbao. Synthesis of the related substances of deferasirox[J]. Journal of China Pharmaceutical University, 2016, 47(3): 288-290. DOI: 10.11665/j.issn.1000-5048.20160306
Citation:
LUO Yan, GU Jinhua, LUO Zhiteng, WU Jie, YE Lianbao. Synthesis of the related substances of deferasirox[J]. Journal of China Pharmaceutical University, 2016, 47(3): 288-290. DOI: 10.11665/j.issn.1000-5048.20160306
Synthesis of the related substances of deferasirox
To perform the quality control of deferasirox and establish its quality criterion, three related substances which were determined by analyzing the synthetic route were synthesized, and their structures were confirmed by 1H NMR and MS. These substances were 2-(2-hydroxyphenyl)-4H-benzo［1, 3-e］oxazin-4-one(A), 2-hydroxy-N-(2-hydroxyben-zoyl)-benzamide(B), and methyl-4-［3, 5-bis(2-hydroxyphenyl)- 1H- ［1, 2, 4］triazol-1-yl］-benzoate(C).
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