Effect of oleic acid and isosorbide mononitrate loading on the phase diagrams and<i> in vitro</i> release profiles of glyceryl monooleate liquid crystalline system

ZHANG Xingyi; MA Di; ZHENG Yazhen; XU Liang; GAO Yuan

doi:10.11665/j.issn.1000-5048.20160513

Journal of China Pharmaceutical University > 2016 > 47(5): 581-586. > DOI: 10.11665/j.issn.1000-5048.20160513

ZHANG Xingyi, MA Di, ZHENG Yazhen, XU Liang, GAO Yuan. Effect of oleic acid and isosorbide mononitrate loading on the phase diagrams and in vitro release profiles of glyceryl monooleate liquid crystalline system[J]. Journal of China Pharmaceutical University, 2016, 47(5): 581-586. DOI: 10.11665/j.issn.1000-5048.20160513

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Effect of oleic acid and isosorbide mononitrate loading on the phase diagrams and in vitro release profiles of glyceryl monooleate liquid crystalline system

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The aim of the study was to investigate the effect of oleic acid(OA)and isosorbide mononitrate(ISMN)on the phase diagrams of glyceryl monooleate(GMO)liquid crystalline systems and release of ISMN from them. Liquid crystalline systems of GMO/H₂O, GMO/H₂O/ISMN and GMO/H₂O/OA were prepared and their phase diagrams were plotted. Investigation of water absorption of GMO and ISMN release profiles shown that the release mechanism of ISMN was diffusion-controlled. Increased drug loading accelerated the release rate. However, the increased loading of OA decreased ISMN release. The result could offer practical basis for drug loading and the selection of additives in GMO liquid crystalline system.
- glycery monooleate,
- liquid crystal,
- isosorbide mononitrate,
- oleic acid,
- phase diagrams,
- in-vitro release

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Effect of oleic acid and isosorbide mononitrate loading on the phase diagrams and in vitro release profiles of glyceryl monooleate liquid crystalline system

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