Advanced Search
HUANG Yun, KANG Ziyao, ZHANG Guangqin. Effects of honokiol on TTX-S sodium current in mouse dorsal root ganglion neurons[J]. Journal of China Pharmaceutical University, 2016, 47(5): 609-613. DOI: 10.11665/j.issn.1000-5048.20160518
Citation: HUANG Yun, KANG Ziyao, ZHANG Guangqin. Effects of honokiol on TTX-S sodium current in mouse dorsal root ganglion neurons[J]. Journal of China Pharmaceutical University, 2016, 47(5): 609-613. DOI: 10.11665/j.issn.1000-5048.20160518

Effects of honokiol on TTX-S sodium current in mouse dorsal root ganglion neurons

  • To elucidate possible mechanisms and targets of honokiol(Hnk)for hte treatment of pain, the effects of Hnk on tetrodoxin-senstive(TTX-S)sodium current(INa)were studied in acutely dissociated mouse dorsal root ganglion(DRG)neurons with whole-cell patch clamp technique. Hnk inhibited TTX-S INa currents in a concentration-dependent manner. At 30 μmol/L, Hnk obviously shifted the steady state activation of TTX-S INa toward more positive potentials by 10. 2 mV and prolonged the time course of recovery of sodium current, yet with no significant difference on recovery from inactivation of TTX-S sodium channel.
  • loading

Catalog

    Turn off MathJax
    Article Contents

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return