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XIONG Feng, YAN Bing, DAI Wenling, YU Boyang, LIU Jihua. Analgesic effect of levo-corydalmine on neuropathic pain in rats and its mechanism[J]. Journal of China Pharmaceutical University, 2017, 48(1): 70-75. DOI: 10.11665/j.issn.1000-5048.20170111
Citation: XIONG Feng, YAN Bing, DAI Wenling, YU Boyang, LIU Jihua. Analgesic effect of levo-corydalmine on neuropathic pain in rats and its mechanism[J]. Journal of China Pharmaceutical University, 2017, 48(1): 70-75. DOI: 10.11665/j.issn.1000-5048.20170111
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Analgesic effect of levo-corydalmine on neuropathic pain in rats and its mechanism

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  • The aim of the present study was to investigate the effects of levo-corydalmine(l-CDL)on chronic constrictive injury(CCI)-induced neuropathic pain and central sensitization in spinal cord. The mechanical withdrawal threshold in rats was assessed by Von-Frey fibers and the thermal withdrawal latency was assessed by thermal stimulus apparatus. The level of phosphorylated N-methyl-D-aspartic acid receptor 1(NR1)in L4-L6 spinal cord was analyzed by immunoblotting and the expression of calcitonin gene related peptide(CGRP)and c-fos in spinal cord dorsal horn were analyzed by immunofluorescence. Results showed that l-CDL(7. 5, 15, 30 mg/kg, ig)inhibited CCI-induced mechanical allodynia and thermal hyperalgesia in a dose-dependent manner. l-CDL significantly inhibited the up-regulation of p-NR1, c-fos and CGRP in CCI rats without tolerance. In conclusion, l-CDL has a good relieving effect on central sensitization in spinal cord, thus generating outstanding analgesic activity on CCI-induced neuropathic pain.
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    • References (16)
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