Advances in taste-masking technology of oral paediatric medicine

As children are extremely sensitive to the bad taste of medicine, they have poor compliance with the bitter medicine. It is of great importance to develop the approaches of taste masking for the research of paediatric drug formulations. Besides, taste masking technology is one of the main barrier to develop children pharmaceutic preparation. This article provides an overview of the advance in taste masking technology of oral paediatric medicine in recent years, and introduces five types of taste masking technology in terms of drug, preparation and the bitter taste transduction, including principle and characteristics of these approaches, as well as their application in formulations, so as to provide some references for the development of paediatric medicine.