• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
ZHU Hong, WEI Xiaopeng, JIN Meihua, QIN Nan. Synthesis and inhibition of NO production activities of 1, 6-O, O-diacylbritannilactone derivatives[J]. Journal of China Pharmaceutical University, 2017, 48(4): 440-444. DOI: 10.11665/j.issn.1000-5048.20170408
Citation: ZHU Hong, WEI Xiaopeng, JIN Meihua, QIN Nan. Synthesis and inhibition of NO production activities of 1, 6-O, O-diacylbritannilactone derivatives[J]. Journal of China Pharmaceutical University, 2017, 48(4): 440-444. DOI: 10.11665/j.issn.1000-5048.20170408

Synthesis and inhibition of NO production activities of 1, 6-O, O-diacylbritannilactone derivatives

More Information
  • Eight 1, 6-O, O-diacetylbritannilactone(OABL)derivatives(compounds 1 - 8 )were synthesized by esterification or reduction of 1-O-diacetylbritannilactone(ABL)isolated from Inula japonica. All derivatives were evaluated for their anti-inflammation activities through the determination of inhibition of nitric oxide(NO)production in lipopolysaccharide(LPS)-induced macrophages. As results, compounds 5 - 8 (IC50< 2 μmol/L)exhibited more potent inhibition of NO production activities than the lead compound OABL.
  • [1]
    National Pharmacopoeia Committee.Pharmacopoeia of People′s Republic of China[M].Beijing:The Medicine Science and Technology Press of China,2015:325-326.
    [2]
    Wang GW,Qin JJ,Cheng XR,et al.Inula sesquiterpenoids:structural diversity,cytotoxicity and anti-tumor activity[J].Expert Opin Investig Drugs,2014,23(3):317-345.
    [3]
    Zhu H,Tang SA,Qin N,et al.Anti-inflammatory constituents from Inula japonica[J].China J Chin Mater Med(中国中药杂志),2014,39(1):83-88.
    [4]
    Tang SA,Zhu H,Qin N,et al.Anti-inflammatory terpenes from flowers of Inula japonica[J].Planta Med,2014,80(7):583-589.
    [5]
    Han YW,Zhang YY,Lai XY,et al.Advances of regulatory effects of traditional Chinese medicine on NOS/NO system[J].J China Pharm Univ(中国药科大学学报),2017,48(1):8-15.
    [6]
    Dong S,Tang JJ,Zhang CC,et al.Semisynthesis and in vitro cytotoxic evaluation of new analogues of 1-O-acetylbritannilactone,a sesquiterpene from Inula britannica[J].Eur J Med Chem,2014,80:71-82.
    [7]
    Merten J,Wang Y,Krause T,et al.Total synthesis of the cytotoxic 1,10-seco-eudesmanolides britannilactone and 1,6-O,O-diacetylbritannilactone[J].Chemistry,2011,17(12):3332-3334.
    [8]
    Zhou BN, Bai NS, Lin LZ, et al. Sesquiterpene lactones from Inula britannica[J].Phytochemistry,1993,34(1):249-252.
    [9]
    Zdero C,Bohlmann F,Müller M.Sesquiterpene lactones and other constituents from Eriocephalus species[J].Phytochemistry,1987,26(10):2763-2775.
  • Related Articles

    [1]ZHAO Xiujuan, YANG Hengli, WU Jinye, ZHENG Xiaoqi, ZHANG Yaoping, LIN Yuping, HU Chunyan. Synthesis and anti-inflammatory activity of three series of coumarin-based derivatives[J]. Journal of China Pharmaceutical University, 2025, 56(1): 40-48. DOI: 10.11665/j.issn.1000-5048.2024072101
    [2]GUAN Li, WANG Chunyang, ZHAO Huiru, LI Weize, FENG Feng. Synthesis and biological evaluation of moscatilin analogs as anti-inflammatory agents[J]. Journal of China Pharmaceutical University, 2021, 52(2): 171-176. DOI: 10.11665/j.issn.1000-5048.20210205
    [3]MOU Yi, CHEN Tong, HUANG Zhangjian, LAI Yisheng, PENG Sixun, JI Hui, ZHANG Yihua. Design, synthesis and anti-inflammatory evaluation of CDDO-Me ester prodrugs[J]. Journal of China Pharmaceutical University, 2016, 47(6): 661-665. DOI: 10.11665/j.issn.1000-5048.20160605
    [4]XU Guijun, LI Zhijun, WANG Qi, TAN Jiejun, SHI Guoshan, QI Wei, LI Di, WANG Youpeng. Isolation and identification of anti-inflammatory constituents from Houttuynia cordata[J]. Journal of China Pharmaceutical University, 2016, 47(3): 294-298. DOI: 10.11665/j.issn.1000-5048.20160308
    [5]HU Kun, XU Hua-jin, XIN Wen-qun, CHEN Xin, REN Jie. Synthesis and antitumor activity of nitrogen mustard derivatives of formononetin[J]. Journal of China Pharmaceutical University, 2012, 43(2): 113-119.
    [6]HUANG Wen-xing, LAI Yi-sheng, ZHANG Yi-hua, WANG Zhen-guo, ZHANG Zhi-hao, MA Lin, JI Hui. Synthesis and anti-inflammatory activity of p-(sulfamyl)benzylidene-linked heterocyclic ketone derivatives[J]. Journal of China Pharmaceutical University, 2009, 40(6): 497-502.
    [7]AO Gui-zhen, ZHENG Li-ling, XU Guang-lin, LI Jing. Synthesis and anti-inflammatory activity of α-aryl-3,5-dimethoxyphenylpropenamides[J]. Journal of China Pharmaceutical University, 2009, 40(4): 302-305.
    [8]Synthesis and anti-inflammatory activities of aryl alkyl acid NSAIDs tetraacetylated glucoside derivatives[J]. Journal of China Pharmaceutical University, 2009, 40(1): 26-30.
    [9]Synthesis and anti-inflammatory activities of imidazo[1,2-a] pyrimidine derivatives[J]. Journal of China Pharmaceutical University, 2009, 40(1): 16-20.
    [10]Synthesis and Anti-inflammatory Activity of Nitric Oxidedonating α-Substituted p-(Methanesulfonyl)phenylpropenoic Acid Esters[J]. Journal of China Pharmaceutical University, 2004, (3): 6-10.

Catalog

    Article views (789) PDF downloads (1446) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return