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ZHU Hong, WEI Xiaopeng, JIN Meihua, QIN Nan. Synthesis and inhibition of NO production activities of 1, 6-O, O-diacylbritannilactone derivatives[J]. Journal of China Pharmaceutical University, 2017, 48(4): 440-444. DOI: 10.11665/j.issn.1000-5048.20170408
Citation: ZHU Hong, WEI Xiaopeng, JIN Meihua, QIN Nan. Synthesis and inhibition of NO production activities of 1, 6-O, O-diacylbritannilactone derivatives[J]. Journal of China Pharmaceutical University, 2017, 48(4): 440-444. DOI: 10.11665/j.issn.1000-5048.20170408
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Synthesis and inhibition of NO production activities of 1, 6-O, O-diacylbritannilactone derivatives

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  • Eight 1, 6-O, O-diacetylbritannilactone(OABL)derivatives(compounds 1 - 8 )were synthesized by esterification or reduction of 1-O-diacetylbritannilactone(ABL)isolated from Inula japonica. All derivatives were evaluated for their anti-inflammation activities through the determination of inhibition of nitric oxide(NO)production in lipopolysaccharide(LPS)-induced macrophages. As results, compounds 5 - 8 (IC50< 2 μmol/L)exhibited more potent inhibition of NO production activities than the lead compound OABL.
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