Improved process of dexrabeprazole sodium

The aim of the work is to improve the synthetic process of dexrabeprazole sodium, enhance quality and yield of the product, simplify synthetic steps, and offer a stable and feasible process. Starting from 2-［［［4-(3-methoxypropoxy)-3-methylpyridine-2-yl］methyl］ thio］-1H-benzimidazole, dexrabeprazole was produced by asymmetric oxidation reaction with oxidant cumene hydroperoxide in the presence of chiral catalyst tetraisopropyl titanate and L-(+)-tartaric acid diethyl ester. Dexrabeprazole sodium was obtained by the reaction of purified dexrabeprazole with sodium hydroxide in a total yield of 79% with an HPLC purity of > 99. 5%. The structure of dexrabeprazole sodium was confirmed by NMR, IR, elemental analysis and LC-MS. The improved process of dexrabeprazole sodium possesses simple operations, good yield and high purity, which is feasible for industrialization.