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CAI Gongli, CHEN Yu, LIN Shuting, ZHU Dandan, DONG Yiwen, LI Ning, LIU Xiaoxuan. Application of dendrimer-based siRNA delivery systems[J]. Journal of China Pharmaceutical University, 2019, 50(3): 274-288. DOI: 10.11665/j.issn.1000-5048.20190303
Citation: CAI Gongli, CHEN Yu, LIN Shuting, ZHU Dandan, DONG Yiwen, LI Ning, LIU Xiaoxuan. Application of dendrimer-based siRNA delivery systems[J]. Journal of China Pharmaceutical University, 2019, 50(3): 274-288. DOI: 10.11665/j.issn.1000-5048.20190303
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Application of dendrimer-based siRNA delivery systems

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  • Small interfering RNA-based RNA interference(RNAi)is an emerging treatment which has attracted more and more attention from both academia and industry. Studies on clinical translation of siRNA are popular in biomedical field, where safe and efficient carriers are necessary. As novel drug/gene vectors, dendrimers are widely used in siRNA delivery due to their unique and precise structure, multiple terminal groups and nano-sized chemophysical properties. Here, we present an overall view of current studies on dendrimer-based siRNA delivery systems, with the aim to provide an understanding of future siRNA therapeutics which could be used in clinic.
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