Effect of scutellarein on acute pharyngitis in rats

YANG Yang; JIANG Cuihua; JIN Qiaomei; ZHANG Libang; ZHANG Jian; YIN Zhiqi

doi:10.11665/j.issn.1000-5048.20190514

Journal of China Pharmaceutical University > 2019 > 50(5): 600-605. > DOI: 10.11665/j.issn.1000-5048.20190514

YANG Yang, JIANG Cuihua, JIN Qiaomei, ZHANG Libang, ZHANG Jian, YIN Zhiqi. Effect of scutellarein on acute pharyngitis in rats[J]. Journal of China Pharmaceutical University, 2019, 50(5): 600-605. DOI: 10.11665/j.issn.1000-5048.20190514

Citation:

PDF (1787 KB)

Effect of scutellarein on acute pharyngitis in rats

More Information

Graphical Abstract

Abstract

Abstract

In order to investigate the therapeutic effects of scutellarein on acute pharyngitis, 60 rats were randomly divided into five groups: blank group, model group, low-dose scutellarein group, high-dose scutellarein group and positive drug group. HE staining, blood-cell-analyzer, IL-6, IL-1β and TNF-α ELISA kit were used to study the effects of scutellarein on acute pharyngitis in pharyngeal tissue morphology, the counts of white blood cells and neutrophil and the serum concentrations of TNF-α, IL-1β and IL-6. Meanwhile, forty mice were randomly divided into four groups: blank group, low-dose scutellarein group, high-dose scutellarein group and positive drug group. Then, hot plate and writhing test of mice were carried out to study the analgesic effects of scutellarein. Results showed that, compared to the model group, scutellarein improved the physical status of acute pharyngitis rats, reduced the number of white blood cells significantly(P< 0. 05)and decreased the number of neutrophils and the levels of TNF-α, IL-1β and IL-6 in rats serum significantly(P< 0. 01). Meanwhile, scutellarein dramatically improved the pain threshold in hot plate test and decreased the number of writhing mice(P< 0. 01). It can be concluded that scutellarein can be used to treat acute pharyngitis with its anti-inflammatory and analgesic effect.
- scutellarein,
- acute pharyngitis,
- anti-inflammatory,
- analgesic effect

FullText(HTML)

References (15)

References

[1]	Lu L.Study on the effects and mechanism of Chinese medicine Liyan oral liquid on the animal models with acute and chronic pharyngitis(复方利咽口服液对实验性急、慢性咽炎的疗效与作用机制研究)[D].Taiyuan:Shanxi University,2012.
[2]	Principi N,Bianchini S,Baggi E,et al.No evidence for the effectiveness of systemic corticosteroids in acute pharyngitis,community-acquired pneumonia and acute otitis media[J].Eur J Clin Microbiol Infect Dis,2013,32(2):151-160.
[3]	Muzio F, Barucco M, Guerriero F. Diagnosis and treatment of acute pharyngitis/ tonsillitis:a preliminary observational study in general medicine[J].Eur Rev Med Pharmacol Sci,2016,20(23):4950-4954.
[4]	Harminder,Singh V,Chaudhary AK.A review on the taxonomy,ethnobotany,chemistry and pharmacology of Oroxylum indicum Vent[J].Indian J Pharm Sci,2011,73(5):483-490.
[5]	Sung NY,Kim MY,Cho JY.Scutellarein reduces inflammatory responses by inhibiting Src kinase activity[J].Korean J Physiol Pharmacol,2015,19(5):441-449.
[6]	Zhou ZX,Mou SF,Chen XQ,et al.Anti-inflammatory activity of resveratrol prevents inflammation by inhibiting NF-κB in animal models of acute pharyngitis[J].Mol Med Rep,2018,17(1):1269-1274.
[7]	Miao SM,Chang BJ,Ming B,et al.Specification for preparation of animal models of acute pharyngitis(Draft)[J].Pharmacol Clin Chin Mate Med(中药药理和临床),2018,34(1):175-176.
[8]	Liu B,Bai M,Peng M,et al.Anti-inflammatory effect and the effect on acute pharyngitis rats model of compound lobelia oral liquid[J].Saudi J Biol Sci,2019,26(3):577-581.
[9]	Kai Z, Xiaorui Y, Department P. Studies on pharmacological effect of Xiaoer Houbi recipe on acute pharyngitis[J].Asia-Pacific Tradit Med(亚太传统医学),2017,13(8):6-9.
[10]	Hao SQ.The effect of endotoxin induced by heat stress on renal function in broilers(热应激内毒素对肉鸡肾功能的影响)[D].Zhengzhou:Henan Agricultural University,2014.
[11]	Gu H, Yue F, Chen HC. Protective effect of jin lan granules on acute pharyngitis in young rats[J].Acta Chin Med(中医学报),2018,33(11):2160-2163.
[12]	Pelucchi C,Grigoryan L,Galeone C,et al.Guideline for the management of acute sore throat:ESCMID sore throat guideline group[J].Clin Microbiol Infect,2012,18(s1):1-28.
[13]	Wang B,Yuan HJ,Yuan N,et al.Protective effect of baicalin on acute lung injury in rats with endotoxemia[J].Chin J Mod Med(中国现代医学杂志),2016,26(12):15-20.
[14]	Zhao TH,Deng ZS,Gao WY,et al.Study on analgesic effect of scutellarin[J].Chin J Inf Tradit Chin Med(中国中医药信息杂志),2001,8(6):28-29.
[15]	He XH.Studies on the biopharmaceutics and pharmacokinetics of screllarin in rats(灯盏乙素大鼠体内生物药剂学与药物动力学研究)[D]. Shenyang: Shenyang Pharmaceutical University,2005.

Cited By

Get Citation

PDF

XML

Article views (426) PDF downloads (709)

Turn off MathJax

Article Contents

Abstract

References

Effect of scutellarein on acute pharyngitis in rats

Abstract

References

Catalog

Export File

Citation

Format

Content