Research progress of drug delivery system based on black phosphorus in tumor diagnosis and treatment

YANG Huizhen; MU Weiwei; LIU Yongjun; ZHANG Na

doi:10.11665/j.issn.1000-5048.20200303

Journal of China Pharmaceutical University > 2020 > 51(3): 270-276. > DOI: 10.11665/j.issn.1000-5048.20200303

YANG Huizhen, MU Weiwei, LIU Yongjun, ZHANG Na. Research progress of drug delivery system based on black phosphorus in tumor diagnosis and treatment[J]. Journal of China Pharmaceutical University, 2020, 51(3): 270-276. DOI: 10.11665/j.issn.1000-5048.20200303

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Research progress of drug delivery system based on black phosphorus in tumor diagnosis and treatment

Funds: This study was supported by the National Natural Science Foundation of China (No.81773652) and the Young Scholar Program of Shandong University(No. 2017WLJH40)

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Received Date: March 15, 2020
Revised Date: May 02, 2020

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Abstract

Abstract

As a new member of two-dimensional materials, black phosphorus has shown good application prospects in the fields of photoacoustic imaging, photothermal photodynamic therapy, and drug loading due to its excellent characteristics such as good biodegradability, biocompatibility, thickness-dependent tunable direct band-gap, and high surface-to-mass ratio. Because black phosphorus has the characteristics of easy oxidation and degradation, it is coated with relatively stable liposomes or polymeric materials to construct a black phosphorus-based drug delivery system, which shows great potential in tumor treatment and diagnosis and has become a new focus in drug delivery research. In this paper, we introduce the role of black phosphorus in tumor diagnosis and treatment in detail, and summarize the design of black phosphorus-based drug delivery system in recent years as well as its research progress in tumor diagnosis and treatment, in order to provide reference for the research and application of black phosphorus.
- black phosphorus,
- drug delivery,
- tumor diagnosis and treatment,
- photoacoustic imaging,
- photothermal and photodynamic therapy

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[1]	. J Am Chem Soc， 1914， 36（7）： 1344.
[2]	Choi JR， Yong KW， Choi JY， et al. Black phosphorus and its biomedical applications［J］. Theranostics， 2018， 8（4）： 1005-1026.
[3]	Moore C， Jokerst JV. Strategies for image-guided therapy， surgery， and drug delivery using photoacoustic imaging［J］. Theranostics， 2019， 9（6）： 1550-1571.
[4]	Ding K， Zeng JF， Jing LH， et al. Aqueous synthesis of PEGylated copper sulfide nanoparticles for photoacoustic imaging of tumors［J］. Nanoscale， 2015， 7（25）： 11075-11081.
[5]	Cui DD， Shi YJ. Semiconductor single-walled carbon nanotubes for deep tissues near-infrared-II photoacoustic imaging［J］. Acta Laser Biol Sin （激光生物学报）， 2019， 28（5）： 463-467.
[6]	Ge XX， Xia ZH， Guo SJ. Recent advances on black phosphorus for biomedicine and biosensing［J］. Adv Funct Mater， 2019， 29（29）： 1900318.
[7]	Sun ZB， Zhao YT， Li ZB， et al. TiL₄-coordinated black phosphorus quantum dots as an efficient contrast agent for in vivo photoacoustic imaging of cancer［J］. Small， 2017， 13（11）. doi：10.1002/smll.201602896.
[8]	Tao W， Ji XY， Xu XD， et al. Antimonene quantum dots： synthesis and application as near-infrared photothermal agents for effective cancer therapy［J］. Angew Chem Int Ed Engl， 2017， 56（39）： 11896-11900.
[9]	Li XS， Kwon N， Guo T， et al. Innovative strategies for hypoxic-tumor photodynamic therapy［J］. Angew Chem Int Ed Engl， 2018， 57（36）： 11522-11531.
[10]	Yang XY， Wang DY， Zhu JW， et al. Functional black phosphorus nanosheets for mitochondria-targeting photothermal/photodynamic synergistic cancer therapy［J］. Chem Sci， 2019， 10（13）： 3779-3785.
[11]	Zhang M， Wang WT， Cui YJ， et al. Near-infrared light-mediated photodynamic/photothermal therapy nanoplatform by the assembly of Fe₃O₄ carbon dots with graphitic black phosphorus quantum dots［J］. Int J Nanomedicine， 2018， 13： 2803-2819.
[12]	Sun ZB， Xie HH， Tang SY， et al. Ultrasmall black phosphorus quantum dots： synthesis and use as photothermal agents［J］. Angew Chem Int Ed Engl， 2015， 54（39）： 11526-11530.
[13]	Wang H， Yang XZ， Shao W， et al. Ultrathin black phosphorus nanosheets for efficient singlet oxygen generation ［J］. J Am Chem Soc， 2015， 137（35）： 11376-11382.
[14]	Fu HD， Li ZB， Xie HH， et al. Different-sized black phosphorus nanosheets with good cytocompatibility and high photothermal performance［J］. RSC Adv， 2017， 7（24）： 14618-14624.
[15]	Qu GB， Xia T， Zhou WH， et al. Property-activity relationship of black phosphorus at the nano-bio interface： from molecules to organisms［J］. Chem Rev， 2020， 120（4）： 2288-2346.
[16]	Chen WS， Ouyang J， Liu H， et al. Black phosphorus nanosheet-based drug delivery system for synergistic photodynamic/photothermal/chemotherapy of cancer［J］. Adv Mater Weinheim， 2017， 29（5）. doi：10.1002/adma.201603864.
[17]	Jin LG， Hu P， Wang YY， et al. Fast-acting black-phosphorus-assisted depression therapy with low toxicity［J］. Adv Mater Weinheim，2020，32（2）：e1906050.doi：10.1002/adma. 201906050.
[18]	Zhou WH， Pan T， Cui HD， et al. Black phosphorus： bioactive nanomaterials with inherent and selective chemotherapeutic effects［J］. Angew Chem Int Ed Engl， 2019， 58（3）： 769-774.
[19]	Tao W， Zhu XB， Yu XH， et al. Black phosphorus nanosheets as a robust delivery platform for cancer theranostics［J］. Adv Mater Weinheim， 2017， 29（1）. doi：10.1002/adma.201603276.
[20]	Gao NS， Nie JP， Wang HF， et al. A versatile platform based on black phosphorus nanosheets with enhanced stability for cancer synergistic therapy［J］. J Biomed Nanotechnol， 2018， 14（11）： 1883-1897.
[21]	Hai L， Zhang AM， Wu X， et al. Liposome-stabilized black phosphorus for photothermal drug delivery and oxygen self- enriched photodynamic therapy［J］. ACS Appl Nano Mater， 2020， 3（1）： 563-575.
[22]	Shao JD， Xie HH， Huang H， et al. Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy［J］. Nat Commun， 2016， 7： 12967.
[23]	Li ZJ， Xu H， Shao JD， et al. Polydopamine-functionalized black phosphorus quantum dots for cancer theranostics［J］. Appl Mater Today， 2019， 15： 297-304.
[24]	Abri Aghdam M， Bagheri R， Mosafer J， et al. Recent advances on thermosensitive and pH-sensitive liposomes employed in controlled release［J］. J Control Release， 2019， 315： 1-22.
[25]	Zhang LL， Wang YQ， Wang J， et al. Photon-responsive antibacterial nanoplatform for synergistic photothermal-/pharmaco-therapy of skin infection［J］. ACS Appl Mater Interfaces， 2019， 11（1）： 300-310.
[26]	Chen XL， Zhou Y， Liang X， et al. In vitro study of black phosphorus quantum dot-loaded liposomes for photothermal therapy of cervical cancer［J］. Acta Pharm Sin （药学学报）， 2019， 54（4）： 729-736.
[27]	Qiu M， Wang D， Liang WY， et al. Novel concept of the smart NIR-light-controlled drug release of black phosphorus nanostructure for cancer therapy［J］. Proc Natl Acad Sci U S A， 2018， 115（3）： 501-506.
[28]	Shao JD， Ruan CS， Xie HH， et al. Black-phosphorus-incorporated hydrogel as a sprayable and biodegradable photothermal platform for postsurgical treatment of cancer［J］. Adv Sci （Weinh）， 2018， 5（5）： 1700848.
[29]	Zhang F， Peng FF， Qin L， et al. pH/near infrared dual-triggered drug delivery system based black phosphorus nanosheets for targeted cancer chemo-photothermal therapy［J］. Colloids Surf B Biointerfaces， 2019， 180： 353-361.
[30]	Wang SH， Shao JD， Li ZB， et al. Black phosphorus-based multimodal nanoagent： showing targeted combinatory therapeutics against cancer metastasis［J］. Nano Lett， 2019， 19（8）： 5587-5594.
[31]	Tan SZ， Li DP， Zhu X. Cancer immunotherapy： Pros， cons and beyond［J］. Biomed Pharmacother， 2020， 124： 109821.
[32]	Ma YC， Zhang YX， Li XQ， et al. Near-infrared II phototherapy induces deep tissue immunogenic cell death and potentiates cancer immunotherapy［J］. ACS Nano， 2019， 13（10）： 11967-11980.
[33]	Li Z， Hu YH， Fu QR， et al. NIR/ROS-responsive black phosphorus QD vesicles as immunoadjuvant carrier for specific cancer photodynamic immunotherapy［J］. Adv Funct Mater， 2020， 30（3）： 1905758.
[34]	Ye XY， Liang X， Chen Q， et al. Surgical tumor-derived personalized photothermal vaccine formulation for cancer immunotherapy［J］. ACS Nano， 2019， 13（3）： 2956-2968.
[35]	Liang X， Ye XY， Wang C， et al. Photothermal cancer immunotherapy by erythrocyte membrane-coated black phosphorus formulation［J］. J Control Release， 2019， 296： 150-161.
[36]	Wang KK， Zhang YF， Wang J， et al. Self-assembled IR780-loaded transferrin nanoparticles as an imaging， targeting and PDT/PTT agent for cancer therapy［J］. Sci Rep， 2016， 6： 27421.
[37]	Lin Z， Liu Y， Ma XM， et al. Photothermal ablation of bone metastasis of breast cancer using PEGylated multi-walled carbon nanotubes［J］. Sci Rep， 2015， 5： 11709.
[38]	Yang XY， Wang DY， Shi YH， et al. Black phosphorus nanosheets immobilizing Ce6 for imaging-guided photothermal/photodynamic cancer therapy［J］. ACS Appl Mater Interfaces， 2018， 10（15）： 12431-12440.
[39]	Deng LJ， Xu YF， Sun CX， et al. Functionalization of small black phosphorus nanoparticles for targeted imaging and photothermal therapy of cancer［J］. Sci Bull， 2018， 63（14）： 917-924.

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