Progress in technology of long-acting preparations of protein and peptide drugs

DING Yuan; CHEN Xin; TU Jiasheng; SUN Chunmeng

doi:10.11665/j.issn.1000-5048.20200407

Journal of China Pharmaceutical University > 2020 > 51(4): 433-440. > DOI: 10.11665/j.issn.1000-5048.20200407

DING Yuan, CHEN Xin, TU Jiasheng, SUN Chunmeng. Progress in technology of long-acting preparations of protein and peptide drugs[J]. Journal of China Pharmaceutical University, 2020, 51(4): 433-440. DOI: 10.11665/j.issn.1000-5048.20200407

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Progress in technology of long-acting preparations of protein and peptide drugs

1.
Center for Research, Development and Evaluation for Pharmaceutical Excipients and Generic Drugs, China Pharmaceutical University, Nanjing 210009
2.
Center for Drug Evaluation, National Medical Products Administration, Beijing 100022, China

Funds: This study was supported by the National Natural Science Foundation of China (No.81972894, No.81673364), the Chinese Pharmacopoeia Commission “Reform of the Review and Approval System for Drugs and Medical Devices” Project (No.ZG2017-5-03) and the National Science and Technology Major Project for Drug Innovation (No.2017ZX09101001006)

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Received Date: November 08, 2019

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Abstract

Abstract

As one of the most important biological drugs, protein and peptide drugs have been increasingly used in the prevention, diagnosis and treatment of diseases in recent years. However, most of them need to be injected and lack of long-acting formulations, which brings many troubles to patients suffering from chronic diseases. In this review, we summarized the strategies for engineering long-acting formulations for proteins and peptides via preparation means, including extended-release injection, implant, oral preparations and transdermal drug delivery systems, and analyzed their release mechanisms, research advances, advantages and shortcomings, thereby providing potential approaches for promoting the formulation improvement of these drugs.
- protein and peptide drugs,
- long-acting performance,
- extended- and controlled-release,
- formulation improvement,
- advances

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References

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