Studies on the chemical constituents in the aerial parts of <i>Paris polyphylla</i> var. <i>Yunnanensis</i>

TAO Junjie; YANG Jie; WEN Xiaodong

doi:10.11665/j.issn.1000-5048.20200410

Journal of China Pharmaceutical University > 2020 > 51(4): 454-460. > DOI: 10.11665/j.issn.1000-5048.20200410

TAO Junjie, YANG Jie, WEN Xiaodong. Studies on the chemical constituents in the aerial parts of Paris polyphylla var. Yunnanensis[J]. Journal of China Pharmaceutical University, 2020, 51(4): 454-460. DOI: 10.11665/j.issn.1000-5048.20200410

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Studies on the chemical constituents in the aerial parts of Paris polyphylla var. Yunnanensis

State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China

Funds: This study was supported by National Key R&D Program of China (No.2019 YFC1711000) and the National Natural Science Foundation of China(No. 81773877)

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Received Date: February 12, 2020

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Abstract

Six steroidal saponins were isolated from the n-butanol extract of 90% ethanol extract of the aerial parts of Paris polyphylla var. yunnanensis by silica gel for column chromatography, MCI column chromatography and preparative high performance liquid chromatography(HPLC). According to the physicochemical properties and spectral data, they were identified as 26-O-β-D-glucopyranosyl-kryptogenin-3-O-α-L-rhamnopyranosyl-(1→4)-α-L-rhamnopyranosy-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside(1), dioseptemloside G(2), polyphylloside III(3), chonglouoside SL-19(4), protodioscin(5), chonglouoside SL-5(6). Among these, compound 1 was a new compound, and compound 2 was obtained from Paris plants for the first time. The platelet aggregation activities and cytotoxicities of the above compounds were evaluated. The results showed that none of the isolated compounds showed significant platelet aggregation activity; compound 2 and 4 exhibited strong cytotoxicity against human colon adenocarcinoma cell line HT29.
- Paris polyphylla var. yunnanensis,
- steroidal saponins,
- isolation and identification,
- platelet aggregation,
- cytotoxicity

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