• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
LI Lin, WANG Xiaoming, MENG Shufang, CHEN Lin, WANG Haiyan, LIN Pengfei, CHEN Ling. Preparation process and structure confirmation of impurity C of rupatifen fumarate[J]. Journal of China Pharmaceutical University, 2020, 51(5): 530-537. DOI: 10.11665/j.issn.1000-5048.20200504
Citation: LI Lin, WANG Xiaoming, MENG Shufang, CHEN Lin, WANG Haiyan, LIN Pengfei, CHEN Ling. Preparation process and structure confirmation of impurity C of rupatifen fumarate[J]. Journal of China Pharmaceutical University, 2020, 51(5): 530-537. DOI: 10.11665/j.issn.1000-5048.20200504
shu

Preparation process and structure confirmation of impurity C of rupatifen fumarate

Funds: This study was supported by China National Key Hi-Tech Innovation Project for the R&D of Novel Drugs(No.2018ZX09J18108-005) and Fujian Provincal Science and Technology Major Special Project(No.2015YZ0002-2)
More Information
  • Received Date: November 24, 2019
  • Revised Date: August 09, 2020
    Graphical Abstract
    • Abstract
  • The high-purity impurity C was isolated and purified from a new anti-allergic drug, rupatifen, by nucleophilic substitution reaction with bromobutaric acid, and its structure was confirmed by IR, UV, MS, 1H NMR, 13C NMR, DEPT135°,HSQC, HMBC, and 1H-1HCOSY. The preparation process of impurity C in this study was simple and easy to obtain under mild conditions, with the purity of 99.0% and the yield of 25%-30%;and the sample met the target compound by structural confirmation. The preparation process and structure confirmation provided sufficient impurity C reference substance for impurity research of raw materials and preparations of rupatifen fumarate, which laid a solid foundation for quality research of new drugs.
    • FullText(HTML)
    • References (9)
  • [1]
    .2016-06-01.
    [2]
    Fujian Mindong Rejuvenation Pharmaceutical Co.，Ltd.Rupatifen fumarate impurity C， preparation method and detection method thereof：CN，
    201811043105.X［P］.2019-01-11.
    [3]
    Wang C， Zhou MQ， Huang WC. Separation and structural confirmation of 5-methoxybenzo［d］oxazole-2（3H）-thione from key intermediate of omeprazole［J］. Chin J Synth Chem（合成化学）， 2018， 26（4）：284?287.
    [4]
    CFDA.The technical guidelines for the preparation and structural confirmation of chemical drug apis［EB/OL］.（2007-08-23）［2019-10-20］.http：//www.cde.org.cn/zdyz.do？method=largePage &id=2067.
    [5]
    ICH.Impurities in new drug substances（Q3A）［EB/OL］.（2006-10-25）［2019-10-21］.https：//www.ich.org/page/quality-guidelines.
    [6]
    Compania Uriach Y.Rupatadine salt as an antihistaminic agent：CN，
    201180030958. X［P］.2013-03-06［2019-10-20］.
    [7]
    Li LL.Study on the synthesis and impurity of rupatadine fumarate （富马酸卢帕他定的合成及杂质研究）［D］.Hangzhou：Zhejiang University，2015.
    [8]
    Zhao X.synthesis The，structure confirmation and qualitative analysis of rupatadine fumarate （富马酸卢帕他定的化学合成、结构确证和质量分析）［D］.Jinan： Shandong University，2008.
    [9]
    Hu CQ，Zhang X.Current situation and the trend in impurity profiling of chemical drugs［J］.Acta Pharm Sin（药学学报），2019，54（12）：2214?2231.
    • Related Articles

  • Related Articles

    [1]SHI Wenxing, LYU Qing, QU Guiwu, ZHAO Ying, ZHOU Fengmei. Therapeutic effect and mechanism of sodium formononetin-3′-sulphonate on collagen-induced rheumatoid arthritis[J]. Journal of China Pharmaceutical University, 2021, 52(5): 579-585. DOI: 10.11665/j.issn.1000-5048.20210510
    [2]LIN Xiaobing, WANG Hao, ZHANG Junhan, LIN Zihao, YAN Ming, AN Xiaofei. Screening of prostaglandin E2 receptor 4 antagonist from active compounds of Baeckea frutescens L. and its anti-rheumatoid arthritis effect in vivo[J]. Journal of China Pharmaceutical University, 2021, 52(1): 92-99. DOI: 10.11665/j.issn.1000-5048.20210113
    [3]ZHANG Ting, LIAO Hang, CHENG Yuting, WU Xiaohong. Preparation and properties of injectable minocycline hydrochloride microsphere depot[J]. Journal of China Pharmaceutical University, 2021, 52(1): 52-59. DOI: 10.11665/j.issn.1000-5048.20210107
    [4]LIU Bowen, LIU Fulei, WANG Ruyi, XUE Jingwei, LIU Wenyuan, FENG Feng, QU Wei. Chemical constituents of total alkaloids from Picrasma quassioides and its effects on collagen induced arthritis in rats[J]. Journal of China Pharmaceutical University, 2019, 50(5): 585-592. DOI: 10.11665/j.issn.1000-5048.20190512
    [5]WANG Chen, HUANG Xin, JIANG Zhenzhou, ZHANG Luyong. Advances in the role of steroids in rheumatoid arthritis[J]. Journal of China Pharmaceutical University, 2015, 46(6): 757-763. DOI: 10.11665/j.issn.1000-5048.20150621
    [6]WU Qi, WU Qian, LUO Xun. Effects of Cynanchum paniculatum paeonol on apoptosis of articular chondrocyte in rabbits with knee osteoarthritis[J]. Journal of China Pharmaceutical University, 2015, 46(3): 359-363. DOI: 10.11665/j.issn.1000-5048.20150317
    [7]LI Pei, WANG Da-wei, LIU Xiao-dong. Tumor necrosis factor-αand its receptors in rheumatoid arthritis[J]. Journal of China Pharmaceutical University, 2011, 42(3): 276-283.
    [8]JING Li-juan, WANG Mei-mei. Relationship between RANKL/OPG system and typeⅡcollagen-induced arthritis in rats and the intervention of [99Tc]-methylene diphosphonate[J]. Journal of China Pharmaceutical University, 2011, 42(3): 251-254.
    [10]Effect of Tripterygium wilfordii PAP Patcher(TWPP) on Adjuvant Arthritis in Rats[J]. Journal of China Pharmaceutical University, 1995, (4): 223-225.

  • Cited by

    Periodical cited type(3)

    1. 杜泽飞，张国文，孙健玮. 重楼中皂苷类成分抗肿瘤作用及机制研究进展. 云南医药. 2024(02): 73-75 .
    2. 刘天会. 细胞器之间相互作用在非酒精性脂肪性肝病发生发展中的作用. 临床肝胆病杂志. 2023(01): 181-187 .
    3. 曹守莹. 新型吡啶氮唑氮芥化合物与线粒体的作用及其抗肿瘤活性. 湖北理工学院学报. 2021(01): 56-61 .

    Other cited types(6)

Catalog

    Get Citation
    PDF
    XML
    Article views (212) PDF downloads (530) Cited by(9)
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：365731

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return