Clinical application and detection of matrix metalloproteinases in diagnosis

WU Yubing; YIN Lifang; QIN Chao

doi:10.11665/j.issn.1000-5048.20200514

Journal of China Pharmaceutical University > 2020 > 51(5): 614-621. > DOI: 10.11665/j.issn.1000-5048.20200514

WU Yubing, YIN Lifang, QIN Chao. Clinical application and detection of matrix metalloproteinases in diagnosis[J]. Journal of China Pharmaceutical University, 2020, 51(5): 614-621. DOI: 10.11665/j.issn.1000-5048.20200514

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Clinical application and detection of matrix metalloproteinases in diagnosis

Funds: This study was supported by the National Natural Science Foundation of China (No. 81871477)

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Received Date: November 26, 2019
Revised Date: August 04, 2020

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Abstract

Abstract

Recently,an increasing number of studies have found that matrix metalloproteinase (MMPs) are closely related to the severity,diagnosis and prognosis of a variety of diseases. MMPs have therefore also gained increasing attention as a potential biomarker. In this paper,the application of MMPs in the diagnosis of tumors,cardiovascular diseases,inflammatory diseases and neurodegenerative diseases was summarized,and three types of detection methods based on RNA level,protein level and hydrolase activity of MMPs were introduced,which aims to provide some theoretical reference for the study of clinical application of MMPs detection.
- matrix metalloproteinases,
- biomarker,
- disease diagnosis,
- detection technology

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References (50)

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