Advances in point-of-care testing for new corona virus nucleic acid

BAO Yaofei; XUE Qianru; WU Haiping; ZOU Bingjie; SONG Qinxin; ZHOU Guohua

doi:10.11665/j.issn.1000-5048.20200601

Journal of China Pharmaceutical University > 2020 > 51(6): 635-645. > DOI: 10.11665/j.issn.1000-5048.20200601

BAO Yaofei, XUE Qianru, WU Haiping, ZOU Bingjie, SONG Qinxin, ZHOU Guohua. Advances in point-of-care testing for new corona virus nucleic acid[J]. Journal of China Pharmaceutical University, 2020, 51(6): 635-645. DOI: 10.11665/j.issn.1000-5048.20200601

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Advances in point-of-care testing for new corona virus nucleic acid

Funds: This study was supported by the National Natural Science Foundation of China (No.81673390), the Natural Science Foundation of Jiangsu Province (No. BK20191322),the Jiangsu Provincial Science Fund for Distinguished Young Scholars (No.BK20180005) and the Undergraduate Training Programs for Innovation and Entrepreneurship(No.202010316032S)

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Received Date: September 16, 2020
Revised Date: November 08, 2020

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Abstract

Abstract

The corona virus disease 2019 (COVID-19) caused by the new coronavirus (SARS-CoV-2) has spread rapidly around the world,posing a serious threat to the public"s health. As of September 30,2020,the number of infected people in the world has reached 33 million,causing more than 1 million deaths. Normalized nucleic acid detection methods based on lab have long turnaround time and high cost. Therefore,there is an urgent need to develop a convenient method to detect SARS-CoV-2,so as to achieve rapid testing and timely control of the epidemic when resources are limited.This review summarizes the point-of-care testing (POCT) methods developed for SARS-CoV-2 in terms of extraction,amplification and detection,and briefly introduces commercial POCT instruments that integrate these three steps,in order to provide references for emergency response and rapid deployment of COVID-19 and other emerging infectious diseases.
- SARS-CoV-2,
- nucleic acid detection,
- point-of-care testing,
- advances

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References (43)

References

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