Advances of long noncoding RNAs in myocardial fibrosis

LI Xiaoshi; WU Xunxun; ZHENG Zuguo; YANG Hua; LI Ping

doi:10.11665/j.issn.1000-5048.20200602

Journal of China Pharmaceutical University > 2020 > 51(6): 646-654. > DOI: 10.11665/j.issn.1000-5048.20200602

LI Xiaoshi, WU Xunxun, ZHENG Zuguo, YANG Hua, LI Ping. Advances of long noncoding RNAs in myocardial fibrosis[J]. Journal of China Pharmaceutical University, 2020, 51(6): 646-654. DOI: 10.11665/j.issn.1000-5048.20200602

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Advances of long noncoding RNAs in myocardial fibrosis

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Received Date: February 29, 2020
Revised Date: September 24, 2020

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Abstract

Abstract

Accumulating studies have recently shown that long noncoding RNAs (lncRNAs) are involved in the initiation and progression of myocardial fibrosis,a common histological characteristic of heart conditions and prominent global health issues. LncRNAs are prominently served as regulatory molecules via interaction with DNA,RNA and proteins in transcriptional and post-transcriptional processes. They can change morphological structure and biochemical metabolism of cardiac cells and regulate homeostasis of the cardiac extracellular matrix. Therefore,lncRNAs show great potential as diagnostic and prognostic biomarkers and therapeutic targets for anti-fibrotic treatment.
- lncRNAs,
- myocardial fibrosis,
- gene expression regulation,
- biomarker,
- therapeutic target

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References (59)

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