Advances in near infrared photoimmunotherapy of tumor

LI Fang; XIN Junbo; SHI Qin; MAO Chengqiong

doi:10.11665/j.issn.1000-5048.20200604

Journal of China Pharmaceutical University > 2020 > 51(6): 664-674. > DOI: 10.11665/j.issn.1000-5048.20200604

LI Fang, XIN Junbo, SHI Qin, MAO Chengqiong. Advances in near infrared photoimmunotherapy of tumor[J]. Journal of China Pharmaceutical University, 2020, 51(6): 664-674. DOI: 10.11665/j.issn.1000-5048.20200604

Citation:

PDF (27302 KB)

Advances in near infrared photoimmunotherapy of tumor

Funds: This study was supported by the National Natural Science Foundation of China (No.81803452);the Natural Science Foundation of Jiangsu Province (No.BK20180273);

More Information

Received Date: April 19, 2020
Revised Date: September 29, 2020

Graphical Abstract

Abstract

Abstract

Near infrared photoimmunotherapy (NIR-PIT) is a highly selective molecularly targeted phototherapy for cancer which is based on injecting a conjugate of IRDye700DX,a water-soluble near-infrared silicon-phthalocyanine dye,and a monoclonal antibody that targets an antigen on the cancer cell surface. Subsequent local irradiation of NIR light causes the rapid and specific tumor cell death. Due to the good clinical translation prospects of NIR-PIT,this paper summarizes the influencing factors,antitumor mechanism,main challenges and recent strategies,which may benefit for its research and clinical application.
- near infrared photoimmunotherapy,
- tumor,
- targeted photodynamic therapy,
- advances

FullText(HTML)

References (46)

References

[1]	. Nat Med，2011，17（12）：1685?1691.
[2]	Maruoka Y，Furusawa A，Okada R，et al. Combined CD44- and CD25-targeted near-infrared photoimmunotherapy selectively kills cancer and regulatory T cells in syngeneic mouse cancer models［J］. Cancer Immunol Res，2020，8（3）：345?355.
[3]	Sato K，Nagaya T，Mitsunaga M，et al. Near infrared photoimmunotherapy for lung metastases［J］. Cancer Lett，2015，365（1）：112?121.
[4]	Sato K，Nagaya T，Nakamura Y，et al. Near infrared photoimmunotherapy prevents lung cancer metastases in a murine model［J］. Oncotarget，2015，6（23）：19747?19758.
[5]	Kobayashi H，Choyke PL. Near-infrared photoimmunotherapy of cancer［J］. Acc Chem Res，2019，52（8）：2332?2339.
[6]	Zheng L，Tan W，Zhang J，et al. Combining trastuzumab and cetuximab combats trastuzumab-resistant gastric cancer by effective inhibition of EGFR/ErbB2 heterodimerization and signaling［J］. Cancer Immunol Immunother，2014，63（6）：581?586.
[7]	Boeckx C，Blockx L，de Beeck KO，et al. Establishment and characterization of cetuximab resistant head and neck squamous cell carcinoma cell lines：focus on the contribution of the AP-1 transcription factor［J］. Am J Cancer Res，2015，5（6）：1921?1938.
[8]	Sano K，Nakajima T，Choyke PL，et al. Markedly enhanced permeability and retention effects induced by photo-immunotherapy of tumors［J］. ACS Nano，2013，7（1）：717?724.
[9]	Burley TA，Maczynska J，Shah A，et al. Near-infrared photoimmunotherapy targeting EGFR-shedding new light on glioblastoma treatment［J］. Int J Cancer，2018，142（11）：2363?2374.
[10]	Nishimura T，Mitsunaga M，Sawada R，et al. Photoimmunotherapy targeting biliary-pancreatic cancer with humanized anti-TROP2 antibody［J］. Cancer Med，2019，8（18）：7781?7792.
[11]	Kiss B，van den Berg NS，Ertsey R，et al. CD47-targeted near-infrared photoimmunotherapy for human bladder cancer［J］. Clin Cancer Res，2019，25（12）：3561?3571.
[12]	Wei W，Jiang D，Ehlerding EB，et al. CD146-targeted multimodal image-guided photoimmunotherapy of melanoma［J］. Adv Sci （Weinh），2019，6（9）：1801237.
[13]	Isobe Y，Sato K，Nishinaga Y，et al. Near infrared photoimmunotherapy targeting DLL3 for small cell lung cancer［J］. EBioMedicine，2020，52：102632.
[14]	Sato K，Hanaoka H，Watanabe R，et al. Near infrared photoimmunotherapy in the treatment of disseminated peritoneal ovarian cancer［J］. Mol Cancer Ther，2015，14（1）：141?150.
[15]	Nagaya T，Okuyama S，Ogata F，et al. Near infrared photoimmunotherapy using a fiber optic diffuser for treating peritoneal gastric cancer dissemination［J］. Gastric Cancer，2019，22（3）：463?472.
[16]	Nagaya T，Okuyama S，Ogata F，et al. Near infrared photoimmunotherapy targeting bladder cancer with a canine anti-epidermal growth factor receptor （EGFR） antibody［J］. Oncotarget，2018，9（27）：19026?19038.
[17]	Kobayashi H，Griffiths GL，Choyke PL. Near-infrared photoimmunotherapy：photoactivatable antibody-drug conjugates （ADCs）［J］. Bioconjug Chem，2020，31（1）：28?36.
[18]	Li F，Zhao Y，Mao C，et al. RGD-modified albumin nanoconjugates for targeted delivery of a porphyrin photosensitizer［J］. Mol Pharm，2017，14（8）：2793?2804.
[19]	Perez HL，Cardarelli PM，Deshpande S，et al. Antibody-drug conjugates：current status and future directions［J］. Drug Discov Today，2014，19（7）：869?881.
[20]	Amoury M，Bauerschlag D，Zeppernick F，et al. Photoimmunotheranostic agents for triple-negative breast cancer diagnosis and therapy that can be activated on demand［J］. Oncotarget，2016，7（34）：54925?54936.
[21]	Okuyama S，Nagaya T，Sato K，et al. Interstitial near-infrared photoimmunotherapy：effective treatment areas and light doses needed for use with fiber optic diffusers［J］. Oncotarget，2018，9（13）：11159?11169.
[22]	Nakajima T，Sato K，Hanaoka H，et al. The effects of conjugate and light dose on photo-immunotherapy induced cytotoxicity［J］. BMC Cancer，2014，14：389.
[23]	Sato K，Watanabe R，Hanaoka H，et al. Comparative effectiveness of light emitting diodes （LEDs） and lasers in near infrared photoimmunotherapy［J］. Oncotarget，2016，7（12）：14324?14335.
[24]	Peng W，de Bruijn HS，Farrell E，et al. Epidermal growth factor receptor （EGFR） density may not be the only determinant for the efficacy of EGFR-targeted photoimmunotherapy in human head and neck cancer cell lines［J］. Lasers Surg Med，2018，50（5）：513?522.
[25]	Nagaya T，Sato K，Harada T，et al. Near infrared photoimmunotherapy targeting EGFR positive triple negative breast cancer：optimizing the conjugate-light regimen［J］. PLoS One，2015，10（8）：e0136829.
[26]	Kishimoto S，Bernardo M，Saito K，et al. Evaluation of oxygen dependence on in vitro and in vivo cytotoxicity of photoimmunotherapy using IR-700-antibody conjugates［J］. Free Radic Biol Med，2015，85：24?32.
[27]	van Lith SAM，van den Brand D，Wallbrecher R，et al. The effect of subcellular localization on the efficiency of EGFR-targeted VHH photosensitizer conjugates［J］. Eur J Pharm Biopharm，2018，124：63?72.
[28]	Mao C，Zhao Y，Li F，et al. P-glycoprotein targeted and near-infrared light-guided depletion of chemoresistant tumors［J］. J Control Release，2018，286：289?300.
[29]	Nakamura Y，Nagaya T，Sato K，et al. Alterations of filopodia by near infrared photoimmunotherapy：evaluation with 3D low-coherent quantitative phase microscopy［J］. Biomed Opt Express，2016，7（7）：2738?2748.
[30]	Sano K，Mitsunaga M，Nakajima T，et al. Acute cytotoxic effects of photoimmunotherapy assessed by 18F-FDG PET［J］. J Nucl Med，2013，54（5）：770?775.
[31]	Ogata F，Nagaya T，Okuyama S，et al. Dynamic changes in the cell membrane on three dimensional low coherent quantitative phase microscopy （3D LC-QPM） after treatment with the near infrared photoimmunotherapy［J］. Oncotarget，2017，8（61）：104295?104302.
[32]	Nakajima K，Takakura H，Shimizu Y，et al. Changes in plasma membrane damage inducing cell death after treatment with near-infrared photoimmunotherapy［J］. Cancer Sci，2018，109（9）：2889?2896.
[33]	Sato K，Watanabe R，Hanaoka H，et al. Photoimmunotherapy：comparative effectiveness of two monoclonal antibodies targeting the epidermal growth factor receptor［J］. Mol Oncol，2014，8（3）：620?632.
[34]	Sato K，Choyke PL，Kobayashi H. Photoimmunotherapy of gastric cancer peritoneal carcinomatosis in a mouse model［J］. PLoS One，2014，9（11）：e113276.
[35]	Kishimoto S，Oshima N，Yamamoto K，et al. Molecular imaging of tumor photoimmunotherapy：evidence of photosensitized tumor necrosis and hemodynamic changes［J］. Free Radic Biol Med，2018，116：1?10.
[36]	Sato K，Ando K，Okuyama S，et al. Photoinduced ligand release from a silicon phthalocyanine dye conjugated with monoclonal antibodies：a mechanism of cancer cell cytotoxicity after near-infrared photoimmunotherapy［J］. ACS Cent Sci，2018，4（11）：1559?1569.
[37]	Dong H，Wu R，Liu J，et al. Advances in cancer photodynamic therapy［J］. J China Pharm Univ（中国药科大学学报），2016，47（4）：377?387.
[38]	Isoda Y，Piao W，Taguchi E，et al. Development and evaluation of a novel antibody-photon absorber conjugate reveals the possibility of photoimmunotherapy-induced vascular occlusion during treatment in vivo［J］. Oncotarget，2018，9（59）：31422?31431.
[39]	Nagaya T，Okuyama S，Ogata F，et al. Endoscopic near infrared photoimmunotherapy using a fiber optic diffuser for peritoneal dissemination of gastric cancer［J］. Cancer Sci，2018，109（6）：1902?1908.
[40]	Maruoka Y，Nagaya T，Sato K，et al. Near infrared photoimmunotherapy with combined exposure of external and interstitial light sources［J］. Mol Pharm，2018，15（9）：3634?3641.
[41]	Nakajima K，Kimura T，Takakura H，et al. Implantable wireless powered light emitting diode （LED） for near-infrared photoimmunotherapy：device development and experimental assessment in vitro and in vivo［J］. Oncotarget，2018，9（28）：20048?20057.
[42]	Mitsunaga M，Nakajima T，Sano K，et al. Near-infrared theranostic photoimmunotherapy （PIT）：repeated exposure of light enhances the effect of immunoconjugate［J］. Bioconjug Chem，2012，23（3）：604?609.
[43]	Mitsunaga M，Nakajima T，Sano K，et al. Immediate in vivo target-specific cancer cell death after near infrared photoimmunotherapy［J］. BMC Cancer，2012，12：345.
[44]	Okuyama S，Nagaya T，Ogata F，et al. Avoiding thermal injury during near-infrared photoimmunotherapy （NIR-PIT）：the importance of NIR light power density［J］. Oncotarget，2017，8（68）：113194?113201.
[45]	Nakajima T，Sano K，Mitsunaga M，et al. Real-time monitoring of in vivo acute necrotic cancer cell death induced by near infrared photoimmunotherapy using fluorescence lifetime imaging［J］. Cancer Res，2012，72（18）：4622?4628.
[46]	Maruoka Y，Nagaya T，Nakamura Y，et al. Evaluation of early therapeutic effects after near-infrared photoimmunotherapy （NIR-PIT） using luciferase-luciferin photon-counting and fluorescence imaging［J］. Mol Pharm，2017，14（12）：4628?4635.

[1]	CHEN Xin, YANG Qian, YOU Qidong, GUO Xiaoke. Advances of inhibitors targeting MLL1-WDR5 protein-protein interaction[J]. Journal of China Pharmaceutical University, 2022, 53(2): 125-136. DOI: 10.11665/j.issn.1000-5048.20220201
[2]	ZHANG Yuxin, DING Ming, LIU Jun. Research progress of proximity labeling technology based on biotin ligase in proteomics[J]. Journal of China Pharmaceutical University, 2022, 53(1): 18-24. DOI: 10.11665/j.issn.1000-5048.20220103
[3]	MO Xiaofei, XU Xiaoli, WANG Yalou, YOU Qidong. Advances in the HIF-1α/p300 protein-protein interaction inhibitors[J]. Journal of China Pharmaceutical University, 2017, 48(5): 515-522. DOI: 10.11665/j.issn.1000-5048.20170502
[4]	LIU Fang, SUN Haopeng, YOU Qidong. Advances in small-molecule inhibitors targeting Hsp90-Cdc37 protein-protein interaction[J]. Journal of China Pharmaceutical University, 2015, 46(3): 272-278. DOI: 10.11665/j.issn.1000-5048.20150303
[5]	The Effect of Inducer on Enzyme Activity of Dihydropyri midinase[J]. Journal of China Pharmaceutical University, 1999, (3): 60-63.
[6]	Purification and Characterization of Potent Fibrinolytic Enzyme from Earthworm[J]. Journal of China Pharmaceutical University, 1997, (6): 48-51.
[7]	Pharmacokinetic Studies of Nevin Fibrinolytic Enzyme[J]. Journal of China Pharmaceutical University, 1997, (2): 107-110.
[8]	Effect of Astragalus on Fluidity of Lipid Regions and Conformation of Protein of Human Erythrocyte Membranes[J]. Journal of China Pharmaceutical University, 1994, (4): 49-52.
[9]	Interaction of Four Berbamine Derivatives with Erythrocyte Membrane Ca~(2 )-Mg~(2 )-ATPase[J]. Journal of China Pharmaceutical University, 1993, (5): 304-307.
[10]	Wu Wutong. Advances in enzyme drugs[J]. Journal of China Pharmaceutical University, 1982, (3): 59-64.

Cited By

Cited by

Periodical cited type(3)

1.	李锦华，祁萍，乔慧. ALK-TKI耐药后获得性RET融合晚期非小细胞肺癌1例报道并文献复习. 肿瘤防治研究. 2024(08): 703-706 .
2.	王瑞峰，赵相欣，孙印，秦桥花，赵冬梅. 降解FAK的PROTAC分子的设计合成及生物活性研究. 中国药物化学杂志. 2023(07): 481-489 .
3.	王梓灵，郭瑜婕，朱芸芸，陈乐，吴婷，刘大会，黄必胜，杜鸿志. 金花茶有效部位抑制表皮生长因子受体(EGFR)抗非小细胞肺癌的作用机制研究. 中国中药杂志. 2021(20): 5362-5371 .

Other cited types(2)

Get Citation

PDF

XML

Article views (433) PDF downloads (1021) Cited by(5)

Turn off MathJax

Article Contents

Abstract

References

Advances in near infrared photoimmunotherapy of tumor

Abstract

References

Related Articles

Cited by

Periodical cited type(3)

Other cited types(2)

Catalog

Advances in near infrared photoimmunotherapy of tumor

Abstract

References

Related Articles

Cited by

Periodical cited type(3)

Other cited types(2)

Catalog

Export File

Citation

Format

Content