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YANG Jie, LIU Hongming, CHEN Yun, CHEN Ran, ZHANG Jingqing. Pharmacokinetics and in situ intestinal absorption of evodiamine lipidic nanoparticle[J]. Journal of China Pharmaceutical University, 2020, 51(6): 696-701. DOI: 10.11665/j.issn.1000-5048.20200608
Citation: YANG Jie, LIU Hongming, CHEN Yun, CHEN Ran, ZHANG Jingqing. Pharmacokinetics and in situ intestinal absorption of evodiamine lipidic nanoparticle[J]. Journal of China Pharmaceutical University, 2020, 51(6): 696-701. DOI: 10.11665/j.issn.1000-5048.20200608
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Pharmacokinetics and in situ intestinal absorption of evodiamine lipidic nanoparticle

Funds: This study was supported by Chongqing Science and Technology Committee (cstc2017shmsA130028)
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  • Received Date: August 04, 2020
  • Revised Date: October 13, 2020
    Graphical Abstract
    • Abstract
  • The aim of this study was to investigate the in vivo pharmacokinetic behavior characteristics and in situ intestinal absorption characteristics of the evodiamine lipidic nanoparticle in rats. Evodiamine lipidic nanoparticle was prepared by the solvent evaporation methods. The particle size and zeta potential of evodiamine lipidic nanoparticle were measured by dynamic light scattering analysis. Male SD rats were divided into two groups randomly. Each group was given single dose of evodiamine and evodiamine lipidic nanoparticle by gavage at evodiamine dose of 250 mg/kg,respectively. The blood samples were collected at scheduled time points. The content of evodiamine in plasma samples was determined by high performance liquid chromatography (HPLC) method. The main pharmacokinetic parameters of evodiamine and evodiamine lipidic nanoparticle were calculated using DAS 2.1.1 software. Moreover,the single-pass intestinal perfusion model was also established in rats to investigate the in situ intestinal absorption characteristics of evodiamine lipidic nanoparticle. The mean particle size and mean zeta potential of evodiamine lipidic nanoparticle were 180.10 nm and -17.90 mV,respectively. The area under the curve of evodiamine and evodiamine lipidic nanoparticle were (862.60±14.03) and (4084.31±17.21) μg/L·h,respectively,and the peak concentration were (163.40±13.27) and (616.90±21.04) μg/L,respectively. Moreover,the absorption of evodiamine lipidic nanoparticle was significantly higher than that of evodiamine in each segment of intestinal tract in rats (P<0.05). The absorption of evodiamine lipidic nanoparticle in colon was better than those of evodiamine lipidic nanoparticle in stomach,duodenum,jejunum and ileum. The absorption rate constant of evodiamine lipidic nanoparticle in stomach,duodenum,jejunum,ileum and colon were (45.10±6.08)×10-5,(48.20±1.21)×10-5,(22.10±3.18)×10-5,(59.10±1.21)×10-5 and (90.00±3.85)×10-5 s-1,respectively,and the effective permeability coefficient in duodenum,jejunum,ileum and colon was (44.10±0.51)×10-5,(17.21±0.77)×10-5,(35.36±0.31)×10-5 and (40.33±0.34)×10-5 cm/s,respectively.All in all, evodiamine lipidic nanoparticle remarkably improved the in situ intestinal absorption of evodiamine in different segments of the intestinal tract in rats and its oral bioavailability in rats.
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    • References (14)
  • [1]
    .Beijing：China Medical Science Press，2020：266
    [2]
    Li XL，Wu SC，Dong GQ，et al. Natural product evodiamine with borate trigger unit： discovery of potent antitumor agents against colon cancer［J］.ACS Med Chem Lett，2020，11（4）：439?444.
    [3]
    Meng T，Fu SP，He DW，et al. Evodiamine inhibits lipopolysaccharide （LPS）-induced inflammation in BV-2 cells via regulating AKT/nrf2-HO-1/NF-κb signaling axis［J］.Cell Mol Neurobiol，2020.doi： 10.1007/s10571-020-00839-w.
    [4]
    Yang S，Chen J，Tan T，et al. Evodiamine exerts anticancer effects against 143B and MG63 cells through the wnt/β-catenin signaling pathway［J］.Cancer Manag Res，2020，12：2875?2888.
    [5]
    Lin HM，Lin LF，Choi Y，et al. Development and in-vitro evaluation of co-loaded berberine chloride and evodiamine ethosomes for treatment of melanoma［J］.Int J Pharm，2020，581：119278.
    [6]
    Tan QY，Liu S，Chen XL，et al. Design and evaluation of a novel evodiamine-phospholipid complex for improved oral bioavailability［J］.AAPS Pharmscitech，2012，13（2）：534?547.
    [7]
    Zhang JX，Ma PX. Cyclodextrin-based supramolecular systems for drug delivery： recent progress and future perspective［J］.Adv Drug Deliv Rev，2013，65（9）：1215?1233.
    [8]
    Zhou SY，Zhang BW，Wei YF，et al. Enhanced dissolution and oral bioavailability of baicalein by cocrystallization［J］.J China Pharm Univ （中国药科大学学报），2018，49（6）：682?688.
    [9]
    Zhang JQ，Hu JB，Chen DL，et al. Improved absorption and in vivo kinetic characteristics of nanoemulsions containing evodiamine-phospholipid nanocomplex［J］.Int J Nanomed，2014，9：4411?4420.
    [10]
    Liu S，Yang L，Liao H，et al. Pharmacokinetics and bioavailability of evodiamine nanocomplex［J］.Acta Acad Med Mil Tert（第三军医大学学报），2013，35（4）：325?327.
    [11]
    Yan SL，Liu YY，Feng JF，et al. Difference and alteration in pharmacokinetic and metabolic characteristics of low-solubility natural medicines［J］.Drug Metab Rev，2018，50（2）：140?160.
    [12]
    Yan SL，Hu JB，Wang X，et al. Pharmacokinetics and in situintestinal absorption of evodiamine complex water-in-oil nanoemulation［J］.Acad J Second Mil Med Univ（第二军医大学学报），2017，38（2）：249?252.
    [13]
    Zhao J，Liu S，Hu X，et al. Improved delivery of natural alkaloids into lung cancer through woody oil-based emulsive nanosystems［J］.Drug Deliv，2018，25（1）：1426?1437.
    [14]
    Yang YH，Zhao XQ，Du Y，et al. Preparation，spectroscopy and molecular modelling studies of inclusion complex of vincamine with hydroxypropyl-β-cyclodextrin［J］.China Tradit Herb Drugs（中草药），2019，50（2）：93?104.
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