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Chen Yuanyuan, Li Xiangyu, XU Pengfei, LU Xiaokun, WANG Youmei, XU Peng, DI Bin. Research advances of fentanyl and fentanyl-related substances[J]. Journal of China Pharmaceutical University, 2020, 51(6): 724-730. DOI: 10.11665/j.issn.1000-5048.20200612
Citation: Chen Yuanyuan, Li Xiangyu, XU Pengfei, LU Xiaokun, WANG Youmei, XU Peng, DI Bin. Research advances of fentanyl and fentanyl-related substances[J]. Journal of China Pharmaceutical University, 2020, 51(6): 724-730. DOI: 10.11665/j.issn.1000-5048.20200612
shu

Research advances of fentanyl and fentanyl-related substances

Funds: This study was supported by the National Key Research and Development Program of China for the 13th Five-Year Plan (No.2017YFC0803605,No.2018YFC0807402)
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  • Received Date: October 12, 2019
  • Revised Date: October 12, 2020
    Graphical Abstract
    • Abstract
  • Fentanyl and fentanyl-related substances are a series of synthetic and powerful anesthetics represented by fentanyl. In recent years,the abuse and trafficking of these substances in many countries around the world are serious which poses a great threat to people"s health and social stability. This paper focuses on the abuse,pharmacological and toxicological action,detection methods and control of fentanyl and fentanyl-related substances and aims to enhance people"s understanding of their basic properties,current research and control so as to provide references for future research.
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    • References (54)
  • [1]
    . J Beijing Police College（北京警察学院学报），2019（3）：109?115.
    [2]
    Yang LH. Reflection on the management of the whole class of fentanyl substances in China［J］. J Yunnan Police Officer Academy（云南警官学院学报），2019（4）：1?4.
    [3]
    Liu ZM. Abuse and control of fentanyl and its derivatives：hazards and challenges［J］. Chin J Drug Depend（中国药物依赖性杂志），2017，26（4）：274?276.
    [4]
    UNODC. Fentanyl and its anolognes-50 year on［J］. Global SMART Update，2017，17：3?8.
    [5]
    Karila L，Marillier M，Chaumette B，et al. New synthetic opioids：part of a new addiction landscape［J］. Neurosci Biobehav Rev，2019，106：133?140.
    [6]
    Baumann MH，Pasternak GW. Novel synthetic opioids and overdose deaths：tip of the iceberg［J］？ Neuropsychopharmacology，2018，43（1）：216?217.
    [7]
    UNODC. Understanding the global opioid crisis［J］. Global SMART Update，2019，21：6?9.
    [8]
    Burns SM，Cunningham CW，Mercer SL. DARK classics in chemical neuroscience：fentanyl［J］. ACS Chem Neurosci，2018，9（10）：2428?2437.
    [9]
    Comer SD，Cahill CM. Fentanyl：receptor pharmacology，abuse potential，and implications for treatment［J］. Neurosci Biobehav Rev，2019，106：49?57.
    [10]
    Xiao JZ. Pharmacology and clinical practice of remifentanil［J］. J Med Theor Pract （医学理论与实践），2009，22（2）：158?160.
    [11]
    Yang S，Xu Q. Research progress in the fentanyl and its derivatives in the treatment of cancer pain［J］. Shanghai Med Pharm J（上海医药），2015（5）：32?36.
    [12]
    Pacifici GM. Clinical pharmacology of fentanyl in preterm infants. A review［J］. Pediatr Neonatol，2015，56（3）：143?148.
    [13]
    Schaefer CP，Tome ME，Davis TP. The opioid epidemic：a central role for the blood brain barrier in opioid analgesia and abuse［J］. Fluids Barriers CNS，2017，14（1）：32.
    [14]
    Ninkovi? J，Roy S. Role of the mu-opioid receptor in opioid modulation of immune function［J］. Amino Acids，2013，45（1）：9?24.
    [15]
    Xu L，Li YH. Studies on pharmacological action and clinical application of sufentanil［J］. Anhui Med Pharm J（安徽医药），2011（3）：375?377.
    [16]
    Xiao GF，Lv H. Observation on the analgesic effect and stress state of brachial plexus block combined with remifentanil during replantation of severed fingers［J］. J Logist Univ PAPF（武警后勤学院学报），2018，27（6）：48?51.
    [17]
    Ma L，Wang XL. Evaluation of sufentanil in intravenous postoperative analgesia and clinical anesthesia［J］. Gen J Stomat（全科口腔医学杂志），2018，5（32）：191?192.
    [18]
    Dumas EO，Pollack GM. Opioid tolerance development：a pharmacokinetic/pharmacodynamic perspective［J］. AAPS J，2008，10（4）：537?551.
    [19]
    Sutou I，Nakatani T，Hashimoto T，et al. Fentanyl tolerance in the treatment of cancer pain：a case of successful opioid switching from fentanyl to oxycodone at a reduced equivalent dose［J］. J Pain Palliat Care Pharmacother，2015，29（2）：161?165.
    [20]
    Neunhoeffer F，Hanser A，Esslinger M，et al. Ketamine infusion as a counter measure for opioid tolerance in mechanically ventilated children：a pilot study［J］. Paediatr Drugs，2017，19（3）：259?265.
    [21]
    Volkow ND，Jones EB，Einstein EB，et al. Prevention and treatment of opioid misuse and addiction：a review［J］. JAMA Psychiatry，2019，76（2）：208?216.
    [22]
    Hao W，Zhao M，Li J. Addication medicine：theory and practice（成瘾医学：理论和实践）［M］. Beijing：People''''s Medical Publishing House，2016：14?71.
    [23]
    Aceto M. Dependence studies of new compounds in the rhesus monkey，rat and mouse［J］. Problems Drug Dependence ，1996，1998：338.
    [24]
    Pan LS，Cui YY，Ren YH，et al. Dependence -producing potential of remifentanil［J］. Chin J Drug Depend（中国药物依赖性杂志），2002，11（2）：107?110.
    [25]
    Bekhit MH. Opioid-induced hyperalgesia and tolerance［J］. Am J Ther，2010，17（5）：498?510.
    [26]
    YueK，WenRJ. Neuroimmune mechanism of opiates addiction［J］. J Jianghan Univ（Nat Sci Ed.）［江汉大学学报（自然科学版）］，2017，45（3）：241?246.
    [27]
    Essawi MY. Fentanyl analogues with a modified propanamido group as potential affinity labels：synthesis and in vivo activity［J］. Pharmazie，1999，54（4）：307?308.
    [28]
    Lin H，Higgins P，Loh HH，et al. Bidirectional effects of fentanyl on dendritic spines and AMPA receptors depend upon the internalization of mu opioid receptors［J］. Neuropsychopharmacology，2009，34（9）：2097?2111.
    [29]
    Wei X，Wei W. Role of gabapentin in preventing fentanyl-and morphine-withdrawal-induced hyperalgesia in rats［J］. J Anesth，2012，26（2）：236?241.
    [30]
    Dolinak D. Opioid toxicity［J］. Acad Forensic Pathol，2017，7（1）：19?35.
    [31]
    Liu C，Kang Y. How to evaluate and select sedatives and analgesics considering their cardiovascular and respiratory effects［J］？ Chin J Crit Care Intensive Care Med Electron Ed（中华重症医学电子杂志），2017，3（4）：291?295.
    [32]
    Liu XB，Xu GP. Research progress of mechanism about remifentanil slowing down heart rate［J］. Med Recap（医学综述），2012，18（23）：4027?4029.
    [33]
    Chen L，Zhao YH，Liu XL. Progress in the application of sufentanil in the treatment of cancer pain［J］. Chin J Pain Med（中国疼痛医学杂志），2018，24（11）：65?68.
    [34]
    Guo ZF. Clinical application of sufentanil［J］. J Chengde Med Col（承德医学院学报），2016，33（6）：516?519.
    [35]
    Qian ZH，Li P，Zheng H，et al. Mass fragmentation characteristics of fentanyl analogue［J］. J Chin Mass Spectrom Soc（质谱学报），2018，39（5）：79?88.
    [36]
    Gupta PK，Yadav SK，Bhutia YD，et al. Synthesis and comparative bioefficacy of N-（1-phenethyl-4-piperidinyl）propionanilide （fentanyl） and its 1-substituted analogs in Swiss albino mice［J］. Med Chem Res，2013，22（8）：3888?3896.
    [37]
    Swaminathan SK，Fisher J，Kandimalla KK. Sensitive determination of fentanyl in low-volume serum samples by LC-MS/MS［J］. AAPS Pharmscitech，2018，19（7）：2812?2817.
    [38]
    Mochizuki A，Nakazawa H，Adachi N，et al. Identification and quantification of mepirapim and acetyl fentanyl in authentic human whole blood and urine samples by GC-MS/MS and LC-MS/MS［J］. Forensic Toxicol，2018，36（1）：81?87.
    [39]
    Misailidi N，Athanaselis S，Nikolaou P，et al. A GC-MS method for the determination of furanylfentanyl and ocfentanil in whole blood with full validation［J］. Forensic Toxicol，2019，37（1）：238?244.
    [40]
    Liu CM. The application prospect of fourier transform infrared spectroscopy in narcotics control area［J］. Spectrosc Spectral Anal（光谱学与光谱分析），2018，38（S1）：400?401.
    [41]
    Mallette JR，Casale JF，Toske SG，et al. Characterization of （2R，4S）- and （2R，4R）-2-Methylfentanyl and their differentiation from cis- and trans-3-methylfentanyl［J］. Forensic Chem，2018，8：64?71.
    [42]
    Li KK，Miao CY，Wang DK. Detection of drugs by raman spectroscopy and data analysis based on R software［J］. J Light Scat （光散射学报），2018，30（2）：156?162.
    [43]
    Kong LC，Zuo GM，Liu GQ，et al. Surface-enhanced raman spectroscopy for trace fentanyl detection in water［J］. J Light Scat （光散射学报），2010，22（1）：34?38.
    [44]
    Tiscione NB，Wegner K. Validation of the Neogen?Fentanyl ELISA kit for blood and urine［J］. J Anal Toxicol，2017，41（4）：313?317.
    [45]
    Smith JS，Mochel JP，Borts DJ，et al. Adverse reactions to fentanyl transdermal patches in calves：a preliminary clinical and pharmacokinetic study［J］. Vet Anaesth Analg，2018，45（4）：575?580.
    [46]
    Wan HN. Application and development of immunoassay in drug testing and identification［J］. J Liaoning Police Coll（辽宁警察学院学报），2018，20（2）：65?69.
    [47]
    Center For Medical Device Evaluation. NMPA. Notice of issuance of registered designated inspection notice on 30 August，2019［EB/OL］.（2019-08-30）［2019-09-12］.https：//www.cmde.org.cn/CL0151/19680.html.
    [48]
    Zaknoun H，Binette MJ，Tam M. Analyzing fentanyl and fentanyl analogues by ion mob spectrometry［J］. Int J Ion Mobil Spectrom，2019，22（1）：1?10.
    [49]
    UNODC. Recommended methods for the identification and analysis of fentanyl and its analogues in biological specimens：manual for use by national drug analysis laboratories［EB/OL］. （2017-12-07）［2019-11-11］.www.unodc.org/documents/scientific/Recommended_methods_for_the_identification_and_analysis_of_fentanyl.pdf.
    [50]
    Zhang WY，Lin JF，Yan J，et al. Rapid screening of fentanyl substances and their precursors without the standards［J］. J Anal Sci（分析科学学报），2019，35（5）：635?642.
    [51]
    United States Drug Enforcement Administration. Schedules of controlled substances：temporary placement of fentanyl-related substances in schedule I［EB/OL］. （2018-02-06）［2019-11-11］. https：//www.deadiversion.usdoj.gov/fed_regs/rules/2018/fr0206_4.htm.
    [52]
    EMCDDA. Fentanils and synthetic cannabinoids：driving greater complexity into the drug situation-An update from the EU Early Warning System［EB/OL］. （2018-06-01）［2019-11-11］. http：//www.emcdda.europa.eu/publications/rapid-communications/fentanils-and-synthetic-cannabinoids-ews-update_en.
    [53]
    Supreme people''''s court. Notice on the issuance of the catalogue of varieties of narcotic drugs and the catalogue of psychotropic drugs［EB/OL］. （2019-11-11）［2019-11-11］. http：//www.qlgl.gov.cn/show-20-5239-1.html.
    [54]
    China National Narcotic Control Commision. China conducts the management of four fentanyl substances such as carfentanil［EB/OL］. （2017-02-16）［2019-11-11］. http：//www.nncc626.com/2017-02/16/c_129482280_5.htm.
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