Chemical constituents from the stem of <i>Callerya nitida Benth.</i>var<i>.hirsutissima </i>Z.Wei

JIN Chen; HUANG Huilian; HE Yuqin; ZHANG Ling

doi:10.11665/j.issn.1000-5048.20210206

Journal of China Pharmaceutical University > 2021 > 52(2): 177-185. > DOI: 10.11665/j.issn.1000-5048.20210206

JIN Chen, HUANG Huilian, HE Yuqin, ZHANG Ling. Chemical constituents from the stem of Callerya nitida Benth.var.hirsutissima Z.Wei[J]. Journal of China Pharmaceutical University, 2021, 52(2): 177-185. DOI: 10.11665/j.issn.1000-5048.20210206

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Chemical constituents from the stem of Callerya nitida Benth.var.hirsutissima Z.Wei

1.
Jiangxi University of Chinese Medicine, Nanchang 330004
2.
School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China

Funds: This study was supported by the National Natural Science Foundation of China (No.81960697,No.81460595) and the Funded Project of First-Class Discipline of Traditional Chinese Pharmacy in Jiangxi Province (No.JXSYLXK-ZHYA0073)

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Received Date: September 24, 2020
Revised Date: April 02, 2021

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Abstract

Abstract

The chemical constituents from 70% ethanol petroleum ether and n-butanol extractions of Callerya nitita Benth.var.hirsutissima.Z.Wei. were separated by preparative high-performance liquid chromatographic techniques, including repeated column chromatography over macroporous adsorption resin, silica gel, ODS, Sephadex LH-20. The structures of the compounds were identified by their physicochemical properties, spectral data, and mass spectrometry data, in comparison with literature. In our research, one triterpenoids, taraxerone (1), and twenty flavonoids, including genistein-4′-O-β-glucoside (2), 5-hydroxy-4′-methoxyisoflavone-7-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (3), biochanin A 7-O-β-D-apiofuranosyl-(1→5)-β-D-apiofuranosyl- (1→6)-β-D-glucopyranoside (4), formononetin-7-O-β-D-galactopyranoside (5), 5,7-dihydroxy-3′,4′-dimethoxyisoflavone (6), biochanin A-7-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside (7), 5, 7-dihydroxyisoflavone-4′-O-α-L-rhamnopyranosyl-(1→2)-O-β-D-glucopyranoside (8), formononetin-7-O-D-apio-β-D-furanosyl(l→2)-β-D-glucopyranoside (9), 4′-hydroxy-3′-methoxyisoflavone-7-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (10), prunetin (11), prunetin 4′-O-β-D-glucopyranoside (12), pratensein7-O-β-D-glucoside (13), 8-methoxyisoformononetin (14), genistein (15), 3′-hydroxybiochanin A (16), biochanin A (17), 5,7-dihydroxy-3′,5′-dimethoxyisoflavone (18), ononin (19), isoformononetin (20), 5,7,3′,4′-tetrahydroxyflavone (21) were isolated from the two extract parts.Compounds 1-10, 12-14, 16-18, 20 were obtained from this plant, and it is the first time to investigate the plant for the first time.
- Callerya,
- Callerya nitida Benth.var.hirsutissima Z.Wei.,
- chemical constituents,
- petroleum ether extract,
- n-butanol extract

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References

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