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YU Lili, CHU Tingting, HOU Chenzhi, WANG Youmei, DI Bin. Quantitative determination of 10 illicit drugs in wastewater by liquid-liquid extraction-ultra performance liquid chromatography-tandem mass spectrometry[J]. Journal of China Pharmaceutical University, 2021, 52(6): 707-712. DOI: 10.11665/j.issn.1000-5048.20210608
Citation: YU Lili, CHU Tingting, HOU Chenzhi, WANG Youmei, DI Bin. Quantitative determination of 10 illicit drugs in wastewater by liquid-liquid extraction-ultra performance liquid chromatography-tandem mass spectrometry[J]. Journal of China Pharmaceutical University, 2021, 52(6): 707-712. DOI: 10.11665/j.issn.1000-5048.20210608
shu

Quantitative determination of 10 illicit drugs in wastewater by liquid-liquid extraction-ultra performance liquid chromatography-tandem mass spectrometry

  • 1.

    Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009

  • 2.

    China National Narcotics Control Commission- China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control, Nanjing 210009

  • 3.

    Drug Control Information and Technology Center of Ministry of Public Security of the People's Republic of China, Beijing 100741, China

Funds: This study was supported by the National Key Research and Development Program of China (No.2018YFC0807402)
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  • Received Date: April 08, 2021
  • Revised Date: November 08, 2021
    Graphical Abstract
    • Abstract
  • A deuterated internal standard quantitative analysis method based on liquid-liquid extraction-ultra performance liquid chromatography-tandem mass spectrometry (LLE-UPLC-MS/MS) for simultaneous determination of 10 illicit drugs in wastewater was established.Wastewater samples were concentrated by liquid-liquid extraction with dichloromethane: ethyl acetate (1∶1), and separated by a linear gradient of 0.1% formic acid-5 mmol/L ammonium formate aqueous solution and acetonitrile on a C18 column. The samples were then detected by ESI positive ion mode and multiple reaction monitoring mode (MRM) for quantitative analysis.All analytes had a good linear relationship (r ≥ 0.995 7) within the range of their respective standard curves; the limit of quantification was 1 ng/L (except amphetamine at 2.5 ng/L); the relative recovery rate ranged from 96.36% to 106.43%, and the intra- and inter-day precisions were less than 4.70%.This method is accurate, reliable and reproducible, and is suitable for the quantitative determination of 10 illicit drugs in wastewater.It is also suitable for wastewater with complex matrixes that affect solid phase extraction and enrichment.It provides a new analytical method for real-time monitoring of drug abuse.
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    • References (12)
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