• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
MA Jingjie, CHEN Yimeng, JIANG Qixin, YANG Jie, WEN Xiaodong. Effects of ethanol extract of Si Miao Wan on hepatic lipid accumulation[J]. Journal of China Pharmaceutical University, 2021, 52(6): 725-734. DOI: 10.11665/j.issn.1000-5048.20210611
Citation: MA Jingjie, CHEN Yimeng, JIANG Qixin, YANG Jie, WEN Xiaodong. Effects of ethanol extract of Si Miao Wan on hepatic lipid accumulation[J]. Journal of China Pharmaceutical University, 2021, 52(6): 725-734. DOI: 10.11665/j.issn.1000-5048.20210611
shu

Effects of ethanol extract of Si Miao Wan on hepatic lipid accumulation

  • State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China

Funds: This study was supported by the National Key R&D Program of China （No.2018YFC1704500， No.2018YFC1704503）
More Information
  • Received Date: May 16, 2021
  • Revised Date: October 28, 2021
    Graphical Abstract
    • Abstract
  • This study aimed to investigate the ameliorative effects of 60% ethanol elution fraction (ESMW) from Si Miao Wan on the hepatic lipid accumulation and its mechanism.TG kit, BODIPY fluorescence staining, QPCR, WB, oil red O staining, and AMPKα knockdown were used to detect the ability of ESMW to improve lipid accumulation in hepatocytes stimulated with free fatty acid.Furthermore, the effects of ESMW on the oral glucose tolerance, serum biochemical indexes, TG content in liver tissue, the expressions of mRNA and protein related to lipid metabolism in liver tissue were studied in mice fed with high fat diet to verify the mechanism of ESMW fraction on hepatic lipid accumulation.The results showed that ESMW inhibited lipid accumulation induced by free fatty acids by regulating AMPK signaling pathway, and that ESMW significantly improved the lipid metabolism of mice fed with high fat diet, with relation to AMPK signaling pathway.
    • FullText(HTML)
    • References (11)
  • [1]
    . Nat Rev Endocrinol，2019，15（5）：288-298.
    [2]
    Zheng Y，Ley SH，Hu FB.Global aetiology and epidemiology of type 2 diabetes mellitus and its complications［J］.Nat Rev Endocrinol，2018，14（2）：88-98.
    [3]
    Sanyal AJ.Past，present and future perspectives in nonalcoholic fatty liver disease［J］. Nat Rev Gastroenterol Hepatol，2019，16（6）：377-386.
    [4]
    Ota T.Molecular mechanisms of nonalcoholic fatty liver disease （NAFLD）/nonalcoholic steatohepatitis （NASH）［J］. Adv Exp Med Biol，2021，1261：223-229.
    [5]
    Cetin EG，Demir N，Sen I.The relationship between insulin resistance and liver damage in non-alcoholic fatty liver patients［J］. Sisli Etfal Hastan Tip Bul，2020，54（4）：411-415.
    [6]
    Wang CR，Xiang N. Discussion on the relation dysfunction of between liver，spleen and kidney and metabolic syndrome［J］.World Chin Med（世界中医药），2013，8（12）：1412-1413.
    [7]
    Endocrinology and metabolism committee of integrated traditional chinese and western medicine physicians branch of chinesemedical doctor association. guidelines for the diagnosis and treatment of diabetes mellitus with hyperlipidemia［J］. World Chin Med （世界中医药），2021，16（16）：2377-2385.
    [8]
    Hu H，Li LT，Liu YW，et al.Effect of modified simiaosan on inflammatory factors and neuropeptide substances ofpatients with synovitis of knee joint and damp-heat obstruction collateral syndrome［J］.Chin J Exp Tradit Med Form（中国实验方剂学杂志），2020，26（6）：97-102.
    [9]
    Zhao XB，Zhao YK，Li LY. Clinical study on the treatment of acute gouty arthritis by Simiao pills［J］. J New Chin Med（新中医），2021，53（4）：58-60.
    [10]
    Chang WG，Li K，Guan FY，et al.Berberine pretreatment confers cardioprotection against ischemia-reperfusion injury in a rat model of type 2 diabetes［J］. J Cardiovasc Pharmacol Ther，2016，21（5）：486-494.
    [11]
    Cai ZY，Wang CL，Lu TT，et al.Berberine alleviates amyloid-beta pathogenesis via activating LKB1/AMPK signaling in the brain of APP/PS1 transgenic mice［J］. Curr Mol Med，2019，19（5）：342-348.
    • Related Articles

  • Related Articles

    [1]ZHANG Ziling, LU Qian, XU Dengqiu, YU Qinwei, JIANG Zhenzhou. Effect and mechanism of muscle injury on liver lipid metabolism in Duchenne muscular dystrophy mice[J]. Journal of China Pharmaceutical University, 2021, 52(6): 735-741. DOI: 10.11665/j.issn.1000-5048.20210612
    [2]DAI Jiangdong, LI Huipeng, SUN Minjie. Effects of polyethylene glycol length on oral absorption of coumarin 6-loaded nanostructured lipid carrier[J]. Journal of China Pharmaceutical University, 2021, 52(3): 293-300. DOI: 10.11665/j.issn.1000-5048.20210305
    [3]YANG Jie, LIU Hongming, CHEN Yun, CHEN Ran, ZHANG Jingqing. Pharmacokinetics and in situ intestinal absorption of evodiamine lipidic nanoparticle[J]. Journal of China Pharmaceutical University, 2020, 51(6): 696-701. DOI: 10.11665/j.issn.1000-5048.20200608
    [4]LIU Yuanyuan, HE Chao. Preparation，optimization and antibacterial activity of luteolin nanostructured lipid carriers[J]. Journal of China Pharmaceutical University, 2020, 51(6): 681-687. DOI: 10.11665/j.issn.1000-5048.20200606
    [5]CHANG Hui, ZHANG Yameng, DING Xuansheng. Research progress on lipid metabolism in non-small cell lung cancer[J]. Journal of China Pharmaceutical University, 2020, 51(1): 107-113. DOI: 10.11665/j.issn.1000-5048.20200116
    [6]LIN Xia, LI Na, LI Jinwei, YANG Ziyi, JIN Jian. Preparation and evaluation of an oral insulin enteric preparation based on polymer-lipid hybrid nanoparticles[J]. Journal of China Pharmaceutical University, 2019, 50(3): 308-316. DOI: 10.11665/j.issn.1000-5048.20190306
    [7]Studies on the Characteristics of Freeze-Dried Solid Lipid Nanoparticles Loading Mifepristone[J]. Journal of China Pharmaceutical University, 2004, (5): 27-30.
    [8]Effects of Soy Isoflavones on Lipids Metablism Abnormality in Ovariectomized Rats[J]. Journal of China Pharmaceutical University, 2004, (3): 60-64.
    [9]Anti-Lipid Peroxidation and Oxygen Free Radical Scavenging Activity of Pericarpium Citri Reticulatae Extract[J]. Journal of China Pharmaceutical University, 1998, (6): 462-464.
    [10]Inhibitory Effects of Baicalin on Lipid Peroxidation[J]. Journal of China Pharmaceutical University, 1995, (5): 308-310.

Catalog

    Get Citation
    PDF
    XML
    Article views (170) PDF downloads (395) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：414983

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return