Chemical constituents of petroleum ether extract from the stems and leaves of <i>Humulus scandens</i>

SUN Biao; AO Yunlin; WANG Dezhi; WANG Junya; YE Wencai; ZHANG Xiaoqi

doi:10.11665/j.issn.1000-5048.20220207

Journal of China Pharmaceutical University > 2022 > 53(2): 178-184. > DOI: 10.11665/j.issn.1000-5048.20220207

SUN Biao, AO Yunlin, WANG Dezhi, WANG Junya, YE Wencai, ZHANG Xiaoqi. Chemical constituents of petroleum ether extract from the stems and leaves of Humulus scandens[J]. Journal of China Pharmaceutical University, 2022, 53(2): 178-184. DOI: 10.11665/j.issn.1000-5048.20220207

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Chemical constituents of petroleum ether extract from the stems and leaves of Humulus scandens

SUN Biao^1,2,
AO Yunlin^1,2,
WANG Dezhi^1,2,
WANG Junya^1,2,
YE Wencai^1,2,3,
ZHANG Xiaoqi^1,2,3

1.
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Ji'nan University, Guangzhou 510632
2.
Guangdong Engineering Research Center for Modernization of TCM, Ji' nan University, Guangzhou 510632
3.
NMPA Key Laboratory for Quality Evaluation of TCM, Guangzhou 510632, China

Funds: This study was supported by the National Natural Science Foundation of China (No.U1801287, No.82073712), the Science and Technology Planning Project of Guangdong Province (No.2020B1111110004) and the Science and Technology Planning Project of Guangzhou (No.20212210005)

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Received Date: August 26, 2021
Revised Date: February 28, 2022

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Abstract

Abstract

To study the chemical constituents of petroleum ether extract from the stems and leaves of Humulus scandens (family of Moraceae), fifteen compounds were isolated from the stems and leaves of H.scandens by silica gel, Sephadex LH-20, ODS, and preparative HPLC chromatography.The structures were identified by physicochemical data and spectroscopic method as tectochrysin (1), chrysin (2), 5-hydroxy-3, 4'', 6, 7-tetramethoxyflavone (3), (2S)-5-hydroxy-7, 8-dimethoxyflavanone (4), imperatorin (5), phellopterin (6), ethyl 4-hydroxy-3-(3''-methyl-2''-butenyl)benzoate (7), p-hydroxy-phenylpropionic acid (8), ethyl p-hydroxycinnamate (9), p-hydroxybenzaldehyde (10), anofinic acid (11), 5,6-dehydrokavain (12), physcion (13), olean-12-ene-3,?11-dione (14) and ergosta-4, 6, 8 (14), 22-tetraen-3-one (15), respectively.All compounds were isolated from this plant for the first time.
- Moraceae,
- Humulus scandens,
- chemical constitutents,
- flavones

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References (24)

References

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