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TAO Juan, SU Yanhui, ZHOU Yuan, ZHENG Chunli. Preparation and in vivo evaluation of a novel allicin pro-drug tablet[J]. Journal of China Pharmaceutical University, 2022, 53(2): 200-206. DOI: 10.11665/j.issn.1000-5048.20220210
Citation: TAO Juan, SU Yanhui, ZHOU Yuan, ZHENG Chunli. Preparation and in vivo evaluation of a novel allicin pro-drug tablet[J]. Journal of China Pharmaceutical University, 2022, 53(2): 200-206. DOI: 10.11665/j.issn.1000-5048.20220210

Preparation and in vivo evaluation of a novel allicin pro-drug tablet

Funds: This study was supported by Huai''an Science and Technology Development Foundation (No.HAB201717)
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  • Received Date: October 26, 2020
  • Revised Date: March 10, 2022
  • A novel allicin pro-drug tablet containing antacid pellets was developed to realize pH-regulated allicin release and to guarantee allicin yield in stomach environment.Firstly, allicin precursor pellets containing antacid pellet were prepared and artificial gastric juice was used as the medium to determine the yield of the allicin.Then, the total lipid cholesterol (TC), triglyceride cholesterol (TG), high density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C) were used as indicators to study the hypolipidemic effect of allicin precursor pellets in rats.The dissolution test showed that in artificial gastric juice, the yield of allicin-containing antacid pellets exceeded 90%.In pharmacodynamic studies, it was found that antacid pellets showed the expected hypolipidemic effect on hyperlipidemia rats compared without antacid pellets.There was a very significant difference in blood lipid levels between the two test groups (P < 0.05).The allicin pro-drug tablets containing antacid pellets can effectively lower blood lipids.
  • [1]
    . J Nutr,2016,146(2):389S-396S.
    [2]
    Reiter J,Hübbers AM,Albrecht F,et al. Allicin,a natural antimicrobial defence substance from garlic,inhibits DNA gyrase activity in bacteria[J]. Int J Med Microbiol,2020,310(1):151359.
    [3]
    Nasiri A,Ziamajidi N,Abbasalipourkabir R,et al. Beneficial effect of aqueous garlic extract on inflammation and oxidative stress status in the kidneys of type 1 diabetic rats[J]. Indian J Clin Biochem,2017,32(3):329-336.
    [4]
    Zhang Y,Liu XP,Ruan J,et al. Phytochemicals of garlic:promising candidates for cancer therapy[J]. Biomed Pharmacother.,2020,123:109730.
    [5]
    Sobenin IA,Myasoedova VA,Iltchuk MI,et al. Therapeutic effects of garlic in cardiovascular atherosclerotic disease[J]. Chin J Nat Med,2019,17(10):721-728.
    [6]
    Cavallito CJ,Bailey JH. Antibacterial substances from Asarum canadense; isolation,physical properties and antibacterial action[J]. J Am Chem Soc,1946,68:489-492.
    [7]
    Wang HP,Li XX,Liu XY,et al. Influence of pH,concentration and light on stability of allicin in garlic (Allium sativum L.) aqueous extract as measured by UPLC[J]. J Sci Food Agric,2015,95(9):1838-1844.
    [8]
    Liu Y,Li SL,Wu Q,et al. Optimization on extraction process and GC-MS analysis of garlic volatile oil[J]. China Condiment(中国调味品),2018,43(8):118-121.
    [9]
    Chhabria S,Desai K. Purification and characterisation of alliinase produced by Cupriavidus necator and its application for generation of cytotoxic agent:allicin[J]. Saudi J Biol Sci,2018,25(7):1429-1438.
    [10]
    Lawson LD,Wang ZJ. Low allicin release from garlic supplements:a major problem due to the sensitivities of alliinase activity[J]. J Agric Food Chem,2001,49(5):2592-2599.
    [11]
    Lawson L,Hunsaker S. Allicin bioavailability and bioequivalence from garlic supplements and garlic foods[J]. Nutrients,2018,10(7):812.
    [12]
    Zhou Y,Zheng CL,Zhu JB. Preparation of allicin prodrug package tablet[J]. Chin J New Drugs(中国新药杂志),2011,20(23):2316-2320.
    [13]
    Gohel MC,Mehta PR,Dave RK,et al. A more relevant dissolution method for evaluation of floating drug delivery system[J]. Dissolution Technol,2004,11(4):22-25.
    [14]
    Li XX,Shi RM,Liu RT. The main chemical components of garlic and testing standards[J]. J Xinjiang Med Univ (新疆医科大学学报),2020,43(6):697-700.
    [15]
    Steiner M,Khan AH,Holbert D,et al. A double-blind crossover study in moderately hypercholesterolemic men that compared the effect of aged garlic extract and placebo administration on blood lipids[J]. Am J Clin Nutr,1996,64(6):866-870.
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