Preparation and<i> in vivo</i> evaluation of a novel allicin pro-drug tablet

TAO Juan; SU Yanhui; ZHOU Yuan; ZHENG Chunli

doi:10.11665/j.issn.1000-5048.20220210

Journal of China Pharmaceutical University > 2022 > 53(2): 200-206. > DOI: 10.11665/j.issn.1000-5048.20220210

TAO Juan, SU Yanhui, ZHOU Yuan, ZHENG Chunli. Preparation and in vivo evaluation of a novel allicin pro-drug tablet[J]. Journal of China Pharmaceutical University, 2022, 53(2): 200-206. DOI: 10.11665/j.issn.1000-5048.20220210

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Preparation and in vivo evaluation of a novel allicin pro-drug tablet

1.
School of Pharmacy and Traditional Chinese Medicine, Jiangsu College of Nursing, Huai'an 223005
2.
Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China

Funds: This study was supported by Huai''an Science and Technology Development Foundation (No.HAB201717)

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Received Date: October 26, 2020
Revised Date: March 10, 2022

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Abstract

Abstract

A novel allicin pro-drug tablet containing antacid pellets was developed to realize pH-regulated allicin release and to guarantee allicin yield in stomach environment.Firstly, allicin precursor pellets containing antacid pellet were prepared and artificial gastric juice was used as the medium to determine the yield of the allicin.Then, the total lipid cholesterol (TC), triglyceride cholesterol (TG), high density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C) were used as indicators to study the hypolipidemic effect of allicin precursor pellets in rats.The dissolution test showed that in artificial gastric juice, the yield of allicin-containing antacid pellets exceeded 90%.In pharmacodynamic studies, it was found that antacid pellets showed the expected hypolipidemic effect on hyperlipidemia rats compared without antacid pellets.There was a very significant difference in blood lipid levels between the two test groups (P < 0.05).The allicin pro-drug tablets containing antacid pellets can effectively lower blood lipids.
- allicin,
- pro-drug,
- alliin,
- alliinase,
- antacid pellet,
- hyperlipidemia

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References

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