Protective effect and mechanism of <i>Artemisia argyi</i> extract on vancomycin-induced acute kidney injury

LI Da; LI Min; CAI Wenzhi; LIU Wenyuan; XU Jian; YANG Baowei; FENG Feng

doi:10.11665/j.issn.1000-5048.20220215

Journal of China Pharmaceutical University > 2022 > 53(2): 239-244. > DOI: 10.11665/j.issn.1000-5048.20220215

LI Da, LI Min, CAI Wenzhi, LIU Wenyuan, XU Jian, YANG Baowei, FENG Feng. Protective effect and mechanism of Artemisia argyi extract on vancomycin-induced acute kidney injury[J]. Journal of China Pharmaceutical University, 2022, 53(2): 239-244. DOI: 10.11665/j.issn.1000-5048.20220215

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Protective effect and mechanism of Artemisia argyi extract on vancomycin-induced acute kidney injury

1.
Jiangsu Food and Pharmaceutical Science College, Huai'an 223003
2.
Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou 213000
3.
Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009
4.
School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China

Funds: The study was supported by the General Program of Universities in Jiangsu University (No.21KJD350001) and the Natural Science Research Plan of Huai''an (No.HABZ202028)

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Received Date: May 10, 2020
Revised Date: March 20, 2022

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Abstract

Abstract

The goal of the study was to investigate the protective effect and mechanism of Artemisia argyi ethanol extract on chemotherapeutic vancomycin (VAN)-induced acute kidney injury (AKI).The acute kidney injury model of male ICR mice was induced by intraperitoneal injection (ip) of VAN.Thirty mice were divided into the blank group, model group, high dose group, middle dose group and low dose group, which were given medicine by gastric perfusion (ig).Serum levels of cystain C (Cys C), blood urea nitrogen (BUN) and serum creatinine (Scr) were measured, which could reflect renal function of mice.Serum oxidative stress and inflammation indices were also determined, including muscular dystrophy association (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), tumor necrosis factor-alpha (TNF-α), Interleukin-1β (IL-1β), and high-sensitive c-reactive protein (hs-CRP).In addition, hematoxylin-eosin staining (HE) was employed for measuring the damage of renal tissues and the content of apoptosis b-cell lymphoma-2 (Bcl-2), Bcl-2 assaciated X protein (Bax) and caspase-3 were measured too.All results showed that Artemisia argyi extract exhibits protective effect on chemotherapeutic VAN-induced AKI, whose mechanism could be related to the oxidative stress, inflammatory reaction and apoptosis.
- Artemisia argyi extract,
- acute kidney injury,
- mechanism,
- vancomycin

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