Progress in lipid emulsions as antidotes to reverse drug poisoning

LI Zhi; LI Meng; SUN Hao; LIU Dongfei

doi:10.11665/j.issn.1000-5048.20220313

Journal of China Pharmaceutical University > 2022 > 53(3): 348-355. > DOI: 10.11665/j.issn.1000-5048.20220313

LI Zhi, LI Meng, SUN Hao, LIU Dongfei. Progress in lipid emulsions as antidotes to reverse drug poisoning[J]. Journal of China Pharmaceutical University, 2022, 53(3): 348-355. DOI: 10.11665/j.issn.1000-5048.20220313

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Progress in lipid emulsions as antidotes to reverse drug poisoning

1.
State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009
2.
Department of Emergency Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

Funds: This study was supported by the National Natural Science Foundation of China (No.82172184, No.81973266)

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Received Date: December 13, 2021
Revised Date: April 28, 2022

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Abstract

Abstract

Due to their good safety, wide application scope and quick onset time, lipid emulsions are full of promise to reverse drug poisoning. In this review, a number of clinical case reports were summarized to analyze the detoxification effect of lipid emulsions on local anesthetic, antiarrhythmic, psychotropic and organophosphate poisoning, as well as the possible adverse reactions of lipid emulsions therapy.Meanwhile, the mechanisms underlying lipid emulsions therapy, such as lipid sink theory, enhanced body basal metabolism and positively affected cardiovascular function, were fully interpreted.Besides, a few potential solutions to the problems still existing in lipid emulsions therapy were proposed, in order to consolidate the understanding of lipid emulsions therapy and promote its rational application in reversing drug poisoning.
- lipid emulsion,
- antidote,
- drug poisoning,
- detoxification mechanism,
- lipid sink theory

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References (58)

References

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