• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
SHA Kang, LI Jiachen, QI Xiaole. Application and research progress of in situ gel for local treatment of periodontitis[J]. Journal of China Pharmaceutical University, 2022, 53(3): 365-375. DOI: 10.11665/j.issn.1000-5048.20220315
Citation: SHA Kang, LI Jiachen, QI Xiaole. Application and research progress of in situ gel for local treatment of periodontitis[J]. Journal of China Pharmaceutical University, 2022, 53(3): 365-375. DOI: 10.11665/j.issn.1000-5048.20220315
shu

Application and research progress of in situ gel for local treatment of periodontitis

  • Department of Pharmaceutics,School of Pharmacy, China Pharmaceutical University,Nanjing 211198, China

More Information
  • Received Date: January 05, 2022
  • Revised Date: April 06, 2022
    Graphical Abstract
    • Abstract
  • Recently, in situ gel has been widely used as a local delivery system for periodontitis treatment because of its lesion injectability, local drug depot function, and drug sustained-release effect.Different therapeutic purposes can be achieved by loading different types of drugs such as antibiotics, bioactive factors, etc.In this review, different types of in situ gel with temperature-sensitive, ion-sensitive, pH-sensitive and solvent-exchanged characteristics were introduced for their applications and limitations in the delivery of drug for periodontitis;and the elimination of periodontal inflammation, periodontal tissue repair and the long-term role after loading microsphere achieved by the in situ gel system were also reviewed.
    • FullText(HTML)
    • References (75)
  • [1]
    . Periodontol 2000，2020，82（1）：257-267.
    [2]
    Kü?üktürkmen B，?z UC，Topta? M，et al. Development of zoledronic acid containing biomaterials for enhanced guided bone regeneration［J］. J Pharm Sci，2021，110（9）：3200-3207.
    [3]
    Zeng J，Mamitimin M，Song Y，et al. Chairside administrated antibacterial hydrogels containing berberine as dental temporary stopping for alveolar ridge preservation［J］. Eur Polym J，2021，160：110808.
    [4]
    Chowhan A，Giri TK. Polysaccharide as renewable responsive biopolymer for in situ gel in the delivery of drug through ocular route［J］. Int J Biol Macromol，2020，150：559-572.
    [5]
    Ranch KM，Maulvi FA，Koli AR，et al. Tailored doxycycline hyclate loaded in situ gel for the treatment of periodontitis：optimization，in vitro characterization，and antimicrobial studies［J］. AAPS PharmSciTech，2021，22（3）：77.
    [6]
    Taymouri S，Shahnamnia S，Mesripour A，et al. In vitro and in vivo evaluation of an ionic sensitive in situ gel containing nanotransfersomes for aripiprazole nasal delivery［J］. Pharm Dev Technol，2021，26（8）：867-879.
    [7]
    Kouchak M，Mahmoodzadeh M，Farrahi F. Designing of a pH-triggered carbopol?/HPMC in situ gel for ocular delivery of dorzolamide HCl：in vitro，in vivo，and ex vivo evaluation［J］. AAPS PharmSciTech，2019，20（5）：210.
    [8]
    Augustine R，Hasan A，Dalvi YB，et al. Growth factor loaded in situ photocrosslinkable poly（3-hydroxybutyrate-co-3-hydroxyvalerate）/gelatin methacryloyl hybrid patch for diabetic wound healing［J］. Mater Sci Eng C Mater Biol Appl，2021，118：111519.
    [9]
    Huang J，Wang ZR，Krishna S，et al. Environment-sensitive hydrogels as potential drug delivery systems for the treatment of periodontitis［J］. Mat Express，2020，10（7）：975-985.
    [10]
    Okur Nü，Ya?c?lar AP，Siafaka PI. Promising polymeric drug carriers for local delivery：the case of in situ gels［J］. Curr Drug Deliv，2020，17（8）：675-693.
    [11]
    Nasra MMA，Khiri HM，Hazzah HA，et al. Formulation，in-vitro characterization and clinical evaluation of curcumin in situ gel for treatment of periodontitis［J］. Drug Deliv，2017，24（1）：133-142.
    [12]
    Kanwar N，Sinha VR. In situ forming depot as sustained-release drug delivery systems［J］. Crit Rev Ther Drug Carrier Syst，2019，36（2）：93-136.
    [13]
    Wang XQ，Ma JL，Zhu XM，et al. Minocycline-loaded in situ hydrogel for periodontitis treatment［J］. Curr Drug Deliv，2018，15（5）：664-671.
    [14]
    Juvekar S，Kathpalia H. Solvent removal precipitation based in situ forming implant for controlled drug delivery in periodontitis［J］. J Control Release，2017，251：75-81.
    [15]
    Sah AK，Dewangan M，Suresh PK. Potential of chitosan-based carrier for periodontal drug delivery［J］. Colloids Surf B Biointerfaces，2019，178：185-198.
    [16]
    Guo JP，Li O，Fu XD. In vitro characteristics and pharmacodynamics evaluation on rats with periodontitis of doxycycline hydrochloride microspheres/temperature-sensitive gel［J］. J Clin Stomatol（临床口腔医学杂志），2016，32（12）：714-717.
    [17]
    Boonlai W，Tantishaiyakul V，Hirun N，et al. Thermosensitive poloxamer 407/poly（acrylic acid） hydrogels with potential application as injectable drug delivery system［J］. AAPS Pharmscitech，2018，19（5）：2103-2117.
    [18]
    Rangabhatla ASL，Tantishaiyakul V，Boonrat O，et al. Novel in situ mucoadhesive gels based on Pluronic F127 and xyloglucan containing metronidazole for treatment of periodontal disease［J］. Iran Polym J，2017，26（11）：851-859.
    [19]
    Liu T，Chu B. Formation of homogeneous gel-like phases by mixed triblock copolymer micelles in aqueous solution：FCC to BCC phase transition［J］. J Appl Crystallogr，2000，33（3）：727-730.
    [20]
    Rattanasuwan K，Rassameemasmaung S，Sangalungkarn V，et al. Clinical effect of locally delivered gel containing green tea extract as an adjunct to non-surgical periodontal treatment［J］. Odontology，2016，104（1）：89-97.
    [21]
    Ranch KM，Maulvi FA，Naik MJ，et al. Optimization of a novel in situ gel for sustained ocular drug delivery using Box-Behnken design：in vitro，ex vivo，in vivo and human studies［J］. Int J Pharm，2019，554：264-275.
    [22]
    Vanderstraeten M，Gutermuth J，Grosber M. Contact anaphylaxis to poloxamer 188 and 407 in a periodontal gel［J］. Contact Dermatitis，2021，85（2） ：253 - 255.
    [23]
    Liu SY，Wang YN，Ma BJ，et al. Gingipain-responsive thermosensitive hydrogel loaded with SDF-1 facilitates in situ periodontal tissue regeneration［J］. ACS Appl Mater Interfaces，2021，13（31）：36880-36893.
    [24]
    Xu X，Liu H，Guo JM，et al. Intragastric amorphous calcium carbonate consumption triggered generation of in situ hydrogel piece for sustained drug release［J］. Int J Pharm，2020，590：119880.
    [25]
    Obaidat AA，Altamimi RM，Hammad MM. Formulation and release of doxycycline HCL from an ion activated in situ gelling delivery system for the treatment of periodontal disease［J］. J Appl Polym Sci，2010，115（2）：811-816.
    [26]
    Swain GP，Patel S，Gandhi J，et al. Development of moxifloxacin hydrochloride loaded in situ gel for the treatment of periodontitis：in-vitro drug release study and antibacterial activity［J］. J Oral Biol Craniofac Res，2019，9（3）：190-200.
    [27]
    Ni XM，Guo Q，Zou YQ，et al. Preparation and characterization of bear bile-loaded pH sensitive in situ gel eye drops for ocular drug delivery［J］. Iran J Basic Med Sci，2020，23（7）：922-929.
    [28]
    Nimmo CM，Owen SC，Shoichet MS. Diels-Alder Click cross-linked hyaluronic acid hydrogels for tissue engineering［J］. Biomacromolecules，2011，12（3）：824-830.
    [29]
    Park SH，Seo JY，Park JY，et al. An injectable，click-crosslinked，cytomodulin-modified hyaluronic acid hydrogel for cartilage tissue engineering［J］. NPG Asia Mater，2019，11：30.
    [30]
    Wang XY，Burgess DJ. Drug release from in situ forming implants and advances in release testing［J］. Adv Drug Deliv Rev，2021，178：113912.
    [31]
    Suh MS，Kastellorizios M，Tipnis N，et al. Effect of implant formation on drug release kinetics of in situ forming implants［J］. Int J Pharm，2021，592：120105.
    [32]
    Chantadee T，Santimaleeworagun W，Phorom Y，et al. Vancomycin HCl-loaded lauric acid in situ-forming gel with phase inversion for periodontitis treatment［J］. J Drug Deliv Sci Technol，2020，57：101615.
    [33]
    Li ZX，Mu HL，Weng Larsen S，et al. An in vitro gel-based system for characterizing and predicting the long-term performance of PLGA in situ forming implants［J］. Int J Pharm，2021，609：121183.
    [34]
    Qin YY，Yuan ML，Li L，et al. Formulation and evaluation of in situ forming PLA implant containing tinidazole for the treatment of periodontitis［J］. J Biomed Mater Res B Appl Biomater，2012，100（8）：2197-2202.
    [35]
    Lwin WW，Puyathorn N，Senarat S，et al. Emerging role of polyethylene glycol on doxycycline hyclate-incorporated Eudragit RS in situ forming gel for periodontitis treatment［J］. J Pharm Investig，2020，50（1）：81-94.
    [36]
    Phaechamud T，Setthajindalert O. Cholesterol in situ forming gel loaded with doxycycline hyclate for intra-periodontal pocket delivery［J］. Eur J Pharm Sci，2017，99：258-265.
    [37]
    Rein SMT，Lwin WW，Tuntarawongsa S，et al. Meloxicam-loaded solvent exchange-induced in situ forming beta-cyclodextrin gel and microparticle for periodontal pocket delivery［J］. Mater Sci Eng C Mater Biol Appl，2020，117：111275.
    [38]
    Mei LL，Huang XT，Xie YC，et al. An injectable in situ gel with cubic and hexagonal nanostructures for local treatment of chronic periodontitis［J］. Drug Deliv，2017，24（1）：1148-1158.
    [39]
    Fonseca-Santos B，Bonifácio BV，Baub TM，et al. In-situ gelling liquid crystal mucoadhesive vehicle for curcumin buccal administration and its potential application in the treatment of oral candidiasis［J］. J Biomed Nanotechnol，2019，15（6）：1334-1344.
    [40]
    Liu JY，Xiao Y，Wang XY，et al. Glucose-sensitive delivery of metronidazole by using a photo-crosslinked chitosan hydrogel film to inhibit Porphyromonas gingivalis proliferation［J］. Int J Biol Macromol，2019，122：19-28.
    [41]
    Chichiricco PM，Riva R，Thomassin JM，et al. In situ photochemical crosslinking of hydrogel membrane for guided tissue regeneration［J］. Dent Mater，2018，34（12）：1769-1782.
    [42]
    Cobb CM，Sottosanti JS. A re-evaluation of scaling and root planing［J］. J Periodontol，2021，92（10）：1370-1378.
    [43]
    McKenna AM，Ioannidou E，Banach DB. Antibiotic prescribing at a periodontal residency practice in Connecticut［J］. J Periodontol，2021，92（8）：e76-e83.
    [44]
    Raval M，Bagada H. Formulation and evaluation of cyclodextrin-based thermosensitive in situ gel of azithromycin for periodontal delivery［J］. J Pharm Innov，2021，16（1）：67-84.
    [45]
    Agossa K，Sy K，Mainville T，et al. Antibiotic use in periodontal therapy among French dentists and factors which influence prescribing practices［J］. Antibiotics （Basel），2021，10（3）：303.
    [46]
    Xu XW，Gu ZY，Chen X，et al. An injectable and thermosensitive hydrogel：promoting periodontal regeneration by controlled-release of aspirin and erythropoietin［J］. Acta Biomater，2019，86：235-246.
    [47]
    Bansal M，Mittal N，Yadav SK，et al. Periodontal thermoresponsive，mucoadhesive dual antimicrobial loaded in situ gel for the treatment of periodontal disease：preparation，in-vitro characterization and antimicrobial study［J］. J Oral Biol Craniofac Res，2018，8（2）：126-133.
    [48]
    Abdelaziz D，Hefnawy A，Al-Wakeel E，et al. New biodegradable nanoparticles-in-nanofibers based membranes for guided periodontal tissue and bone regeneration with enhanced antibacterial activity［J］. J Adv Res，2020，28：51-62.
    [49]
    Xu C，Lei C，Meng LY，et al. Chitosan as a barrier membrane material in periodontal tissue regeneration［J］. J Biomed Mater Res B Appl Biomater，2012，100（5）：1435-1443.
    [50]
    Pan J，Deng JJ，Yu LM，et al. Investigating the repair of alveolar bone defects by gelatin methacrylate hydrogels-encapsulated human periodontal ligament stem cells［J］. J Mater Sci Mater Med，2019，31（1）：3.
    [51]
    Barros J，Ferraz MP，Azeredo J，et al. Alginate-nanohydroxyapatite hydrogel system：Optimizing the formulation for enhanced bone regeneration［J］. Mater Sci Eng C Mater Biol Appl，2019，105：109985.
    [52]
    Woo HN，Cho YJ，Tarafder S，et al. The recent advances in scaffolds for integrated periodontal regeneration［J］. Bioact Mater，2021，6（10）：3328-3342.
    [53]
    Zhang L，Dong YS，Zhang N，et al. Potentials of sandwich-like chitosan/polycaprolactone/gelatin scaffolds for guided tissue regeneration membrane［J］. Mater Sci Eng C Mater Biol Appl，2020，109：110618.
    [54]
    Liao F，Chen YY，Li ZB，et al. A novel bioactive three-dimensional beta-tricalcium phosphate/chitosan scaffold for periodontal tissue engineering［J］. J Mater Sci Mater Med，2010，21（2）：489-496.
    [55]
    Rather HA，Jhala D，Vasita R. Dual functional approaches for osteogenesis coupled angiogenesis in bone tissue engineering［J］. Mater Sci Eng C，2019，103：109761.
    [56]
    Curvello R，Raghuwanshi VS，Garnier G. Engineering nanocellulose hydrogels for biomedical applications［J］. Adv Colloid Interface Sci，2019，267：47-61.
    [57]
    Ibrahim M，Labaki M，Giraudon JM，et al. Hydroxyapatite，a multifunctional material for air，water and soil pollution control：a review［J］. J Hazard Mater，2020，383：121139.
    [58]
    Guan X，Wu QP，Zhang XW，et al. In-situ crosslinked single ion gel polymer electrolyte with superior performances for lithium metal batteries［J］. Chem Eng J，2020，382：122935.
    [59]
    Pan YS，Zhao Y，Kuang R，et al. Injectable hydrogel-loaded nano-hydroxyapatite that improves bone regeneration and alveolar ridge promotion［J］. Mater Sci Eng C Mater Biol Appl，2020，116：111158.
    [60]
    de Witte TM，Fratila-Apachitei LE，Zadpoor AA，et al. Bone tissue engineering via growth factor delivery：from scaffolds to complex matrices［J］. Regen Biomater，2018，5（4）：197-211.
    [61]
    Garg T，Singh O，Arora S，et al. Scaffold：a novel carrier for cell and drug delivery［J］. Crit Rev Ther Drug Carrier Syst，2012，29（1）：1-63.
    [62]
    Peyvandi AA，Roozbahany NA，Peyvandi H，et al. Critical role of SDF-1/CXCR4 signaling pathway in stem cell homing in the deafened rat cochlea after acoustic trauma［J］. Neural Regen Res，2018，13（1）：154-160.
    [63]
    Fatica A，Bozzoni I. Long non-coding RNAs：new players in cell differentiation and development［J］. Nat Rev Genet，2014，15（1）：7-21.
    [64]
    Chenite A，Chaput C，Wang D，et al. Novel injectable neutral solutions of chitosan form biodegradable gels in situ［J］. Biomaterials，2000，21（21）：2155-2161.
    [65]
    Ding T，Kang WY，Li JH，et al. An in situ tissue engineering scaffold with growth factors combining angiogenesis and osteoimmunomodulatory functions for advanced periodontal bone regeneration［J］. J Nanobiotechnology，2021，19（1）：247.
    [66]
    He XT，Li X，Xia Y，et al. Building capacity for macrophage modulation and stem cell recruitment in high-stiffness hydrogels for complex periodontal regeneration：experimental studies in vitro and in rats［J］. Acta Biomater，2019，88：162-180.
    [67]
    Shen XF，Zhang YX，Gu Y，et al. Sequential and sustained release of SDF-1 and BMP-2 from silk fibroin-nanohydroxyapatite scaffold for the enhancement of bone regeneration［J］. Biomaterials，2016，106：205-216.
    [68]
    Tan JL，Zhang M，Hai ZJ，et al. Sustained release of two bioactive factors from supramolecular hydrogel promotes periodontal bone regeneration［J］. ACS Nano，2019，13（5）：5616-5622.
    [69]
    Jo BS，Lee Y，Suh JS，et al. A novel calcium-accumulating peptide/gelatin in situ forming hydrogel for enhanced bone regeneration［J］. J Biomed Mater Res A，2018，106（2）：531-542.
    [70]
    Shafiee A，Kehtari M，Zarei Z，et al. An in situ hydrogel-forming scaffold loaded by PLGA microspheres containing carbon nanotube as a suitable niche for neural differentiation［J］. Mater Sci Eng C Mater Biol Appl，2021，120：111739.
    [71]
    Zhang M，Bai Y，Xu C，et al. Novel optimized drug delivery systems for enhancing spinal cord injury repair in rats［J］. Drug Deliv，2021，28（1）：2548-2561.
    [72]
    Zhang WJ，Xu WG，Ning C，et al. Long-acting hydrogel/microsphere composite sequentially releases dexmedetomidine and bupivacaine for prolonged synergistic analgesia［J］. Biomaterials，2018，181：378-391.
    [73]
    Liu LL，Cui WG. Injectable hydrogel loaded with bone morphogenetic protein-2 microspheres for bacteriostasis and osteogenesis［J］. J Shanghai Jiaotong Univ （Med Sci） （上海交通大学学报 医学版），2020，40 （9） ：1185 - 1192.
    [74]
    Li XW，Liu XH，Ni SL，et al. Enhanced osteogenic healing process of rat tooth sockets using a novel simvastatin-loaded injectable microsphere-hydrogel system［J］. J Craniomaxillofac Surg，2019，47（7）：1147-1154.
    [75]
    Seo JH，Lee SY，Kim S，et al. Monopotassium phosphate-reinforced in situ forming injectable hyaluronic acid hydrogels for subcutaneous injection［J］. Int J Biol Macromol，2020，163：2134-2144.
    • Related Articles

Catalog

    Get Citation
    PDF
    XML
    Article views (221) PDF downloads (576) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    References

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：365460

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return