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SHA Kang, LI Jiachen, QI Xiaole. Application and research progress of in situ gel for local treatment of periodontitis[J]. Journal of China Pharmaceutical University, 2022, 53(3): 365-375. DOI: 10.11665/j.issn.1000-5048.20220315
Citation: SHA Kang, LI Jiachen, QI Xiaole. Application and research progress of in situ gel for local treatment of periodontitis[J]. Journal of China Pharmaceutical University, 2022, 53(3): 365-375. DOI: 10.11665/j.issn.1000-5048.20220315
shu

Application and research progress of in situ gel for local treatment of periodontitis

  • Department of Pharmaceutics,School of Pharmacy, China Pharmaceutical University,Nanjing 211198, China

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  • Received Date: January 05, 2022
  • Revised Date: April 06, 2022
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    • Abstract
  • Recently, in situ gel has been widely used as a local delivery system for periodontitis treatment because of its lesion injectability, local drug depot function, and drug sustained-release effect.Different therapeutic purposes can be achieved by loading different types of drugs such as antibiotics, bioactive factors, etc.In this review, different types of in situ gel with temperature-sensitive, ion-sensitive, pH-sensitive and solvent-exchanged characteristics were introduced for their applications and limitations in the delivery of drug for periodontitis;and the elimination of periodontal inflammation, periodontal tissue repair and the long-term role after loading microsphere achieved by the in situ gel system were also reviewed.
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