Chiral separation of four acidic drugs by micellar electrokinetic chromatography with ionic liquid-based surfactant

YANG Ke; YU Tao

doi:10.11665/j.issn.1000-5048.20220610

Journal of China Pharmaceutical University > 2022 > 53(6): 710-715. > DOI: 10.11665/j.issn.1000-5048.20220610

YANG Ke, YU Tao. Chiral separation of four acidic drugs by micellar electrokinetic chromatography with ionic liquid-based surfactant[J]. Journal of China Pharmaceutical University, 2022, 53(6): 710-715. DOI: 10.11665/j.issn.1000-5048.20220610

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Chiral separation of four acidic drugs by micellar electrokinetic chromatography with ionic liquid-based surfactant

YANG Ke,
YU Tao

School of Science, China Pharmaceutical University,Nanjing 210098, China

Funds: This work was supported by the National Natural Science Foundation of China (No.82073809) and the Project of the Ideological and Political Education in Courses of China Pharmaceutical University (Instrumental Analysis Experiment)

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Received Date: September 13, 2022
Revised Date: October 26, 2022

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Abstract

In this paper, micellar electrokinetic chromatography (MEKC) with glucose-β-cyclodextrin (Glu-β-CD) as chiral selector and ionic liquid surfactant N-butyl-N-methyl pyrrolidine lauryl sulfate ([C₄MP] [C₁₂SO₄]) micelles formed at low pH as a pseudo stationary phase was applied for the chiral separation of four acidic drugs naproxen,warfarin, ketoprofen and ibuprofen.Under the same conditions,significantly improved separation of tested drug enantiomers was achieved with the MEKC system based on [C₄MP][C₁₂SO₄] compared with the system based on the conventional surfactant sodium dodecyl sulfate (SDS).Several primary parameters affecting enantioseparation such as type and proportion of organic modifier, concentration and pH of the running buffer, concentration of chiral selector,concentration of ionic liquid surfactant and applied voltage were systematically investigated.
- capillary electrophoresis,
- ionic liquid,
- micellar electrokinetic chromatography,
- surfactant,
- chiral separation,
- acidic drugs

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