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YANG Nan, ZHANG Xiao, LYU Hui, HUO Meirong, XU Wei. Advances in immune checkpoint inhibitors combined with other treatments[J]. Journal of China Pharmaceutical University, 2023, 54(2): 131-140. DOI: 10.11665/j.issn.1000-5048.20221028002
Citation: YANG Nan, ZHANG Xiao, LYU Hui, HUO Meirong, XU Wei. Advances in immune checkpoint inhibitors combined with other treatments[J]. Journal of China Pharmaceutical University, 2023, 54(2): 131-140. DOI: 10.11665/j.issn.1000-5048.20221028002
shu

Advances in immune checkpoint inhibitors combined with other treatments

  • 1.

    Department of Pharmacy, the First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital), Ji'nan 250014

  • 2.

    School of Pharmacy, China Pharmaceutical University, Nanjing 210098, China

Funds: This study was supported by the Traditional Chinese Medicine Science and Technology Development Program of Shandong Province (No.2019-0372); the Program of Science and Technology Development of Ji''nan (Clinical Medicine Science and Technology Innovation Program) (No.202019176); the Provincial Natural Science Foundation of Shandong (No.ZR2021MH118); Shandong Provincial Postdoctoral Innovation Program in 2021 (No.273219); and China Postdoctoral Science Foundation (No.2022M711972)
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  • Received Date: October 27, 2022
  • Revised Date: April 03, 2023
    Graphical Abstract
    • Abstract
  • As one of the most attention-attracting immunotherapy, immune checkpoint inhibitors (ICIs) have been approved as the first-line drugs for the therapy of various types of cancers.Nevertheless, the single application of ICIs exhibited limited efficacy, and it is easy to develop drug resistance.Therefore, the development of combination therapies become a hot topic in this field to improve the efficacy of ICIs therapy.This article describes some new ICIs targets, reveals the mechanisms of resistance, and introduces the current status of combination other therapies with ICIs therapy systematically including chemotherapy, radiotherapy, hyperthermia, antiangiogenic therapy, tumor vaccines, cytokine therapy and adoptive cellular therapy.Furthermore, the synergistic mechanism of combination therapy to enhance antitumor effect.Thus, this article provides solid references for personalized combination therapy according to the pathological characteristics of patients.
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    • References (78)
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