Drug delivery systems for sensitization of glioblastoma radiotherapy

Glioblastoma is a common malignant tumor in the central nervous system, often exhibiting radiation resistance. Drug delivery systems can help to overcome the blood-brain barrier and targeted delivery of radiation sensitizers to glioblastoma, thereby enhancing the efficacy of radiation therapy, which has received increasing attention. This review focuses on the relationship between radiation resistance and the intrinsic DNA damage repair mechanism, the clearance of reactive oxygen species with DNA and membrane attack, and the rapid proliferation of glioblastoma stem cells. It also discusses the performance of inorganic nanomaterials, organic composite materials, and bionic drug delivery systems in solving the problem of trans-barrier delivery, and summarizes the design method of drug delivery systems for crossing the blood-brain barrier and targeted delivery of radiation sensitizers to glioblastoma, to provide some possible direction for solving the clinical translation problems of nano delivery systems.