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ZHANG Qilu, NIE Ruizhe, WEI Libin, et al. Wogonin ameliorates Aβ1-42 and D-galactose-induced learning and memory impairment in mice[J]. J China Pharm Univ, 2025, 56(2): 207 − 215. DOI: 10.11665/j.issn.1000-5048.2024091301
Citation: ZHANG Qilu, NIE Ruizhe, WEI Libin, et al. Wogonin ameliorates Aβ1-42 and D-galactose-induced learning and memory impairment in mice[J]. J China Pharm Univ, 2025, 56(2): 207 − 215. DOI: 10.11665/j.issn.1000-5048.2024091301

Wogonin ameliorates Aβ1-42 and D-galactose-induced learning and memory impairment in mice

Funds: This study was supported by Shandong Central Government Guiding Local Science and Technology Development Funds Program (YDZX2023082),Taishan Industrial Leadership Talent Program,Zaozhuang Talent Aggregation Project Fund: Shandong Zaozhuang Talent Program (2021, Industrial Innovation Category),Taishan Industrial Innovation Leading Talent,and Shandong Technological Innovation Guiding Program (Central Government Guiding Local Science and Technology Development Funds) (YDZX2023082)
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  • Received Date: September 12, 2024
  • To investigate the effects of Wogonin (WO) on learning and memory impairment, Aβ1-42 was injected intracerebroventricularly to induced a mouse learning and memory impairment model, and D-galactose was injected intraperitoneally to induced a mouse acute aging model. Mice were administered WO (75, 150, or 300 mg/kg) by oral gavage for 28 consecutive days. Cognitive function was assessed using the Morris water maze (MWM), novel object recognition (NOR), and open field tests (OFT). In the Aβ1-42 model, WO treatment (150 and 300 mg/kg) significantly improved the recognition index in the NOR test, while the 150 mg/kg group showed increased target quadrant preference in the MWM test. No changes in the total distance traveled in OFT. In the D-galactose aging model, the 150 mg/kg WO group exhibited increased platform crossings in the MWM test, and all WO doses (75, 150, and 300 mg/kg) enhanced target quadrant preference, with no alterations in spontaneous movement. Western blot analysis revealed that WO significantly attenuated hippocampal apoptosis in both models. These findings suggest that WO ameliorates learning and memory impairment associated with Alzheimer’s disease and aging.

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