ABSORPTION OF BAICALIN IN HUMAN

Injections, tablets and solution of baicalin were given to each normal healthyman for the study of their absorption. The baicalin in urine was separated by ch-romatography and determined by UV spectrophotometric method. The pharmacokinetic data were fitted by nonlinear least square method with pocket-computer. The result showed that the rate peak value of baicalin injection appeared in urine at 0.4hr (Bioavailability : 89.3%), while that of tablets or solution was between 7.5-16.5 hrs ( Bioavailability: 22-36%) . The mean half-life Of baicalin injection ( 1M ) was 0.62 hr. It is eliminated rapidly and thus the dose of intramuscular injection given once a day was unreasonable.