SYNTHESIS OF FLUNARIZINE

Xiang Manwen, Mo Fenzhu, Zhang Shichun, Zhao Ming. SYNTHESIS OF FLUNARIZINE[J]. Journal of China Pharmaceutical University, 1984, (2): 50-52.

Citation:

Xiang Manwen, Mo Fenzhu, Zhang Shichun, Zhao Ming. SYNTHESIS OF FLUNARIZINE[J]. Journal of China Pharmaceutical University, 1984, (2): 50-52.

Citation:

Xiang Manwen, Mo Fenzhu, Zhang Shichun, Zhao Ming. SYNTHESIS OF FLUNARIZINE[J]. Journal of China Pharmaceutical University, 1984, (2): 50-52.

Abstract

Flunarizine, a calcium antagonist, was synthesized from fluobenzene by the reactions of alkylation, hydrolysis, reduction, chlorination and condensation. Its structure was confirmed by 1^HNMR with total yields being about 62%.

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