SYNTHESIS OF LIROXINAN

Kong Rongzu, Fang Chenglin, Hua Weiyi. SYNTHESIS OF LIROXINAN[J]. Journal of China Pharmaceutical University, 1984, (2): 53-54.

Citation:

Kong Rongzu, Fang Chenglin, Hua Weiyi. SYNTHESIS OF LIROXINAN[J]. Journal of China Pharmaceutical University, 1984, (2): 53-54.

Citation:

Kong Rongzu, Fang Chenglin, Hua Weiyi. SYNTHESIS OF LIROXINAN[J]. Journal of China Pharmaceutical University, 1984, (2): 53-54.

Abstract

Liroxinan(Bevantolol),1-(3,4-dimethoxy phenthyl)amino--3(m-tolyloxy)-2-propanol hydrochloride,an adrenergic beta receptor blocker,was prepared from vanillin via two synthetic routes.One is 5-step reactions consisting of methylation, dismutation, chloration, cyanidation and catalytic hydrogenation with total yield being about 52%, and the other is 3—step reactions consisting of methylation, condensation and reduction with total yield being about 66%.

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