TOTAL SYNTHESIS OF R,R-(-)-DAURISOLINE
-
Graphical Abstract
-
Abstract
Daurisoline(1) was identified as a bisbenzyltetrahydroisoquinoline alkaloid bearing one ether linkage. The key intermediates R-(-)-l-(3'-bromo-4' -benzyloxy)benzyl-1-2-methyl-6-methoxy-7-benzyloxy -1,2,3,4-tetrahydroisoquinoline(3) and R-(-)-l-(4'-hydroxy
-
-