Purity of Intermediate Ammoniate and Its Influence on Quality of Amiloride

The Purity of 3,5-diamino-6-chlor-2-methoxy-carboyl-pyrazinge(ammoniate),an intermediate of amiloride was examined by HPLC.The chromatographic determination results of crude ammoniates conformed to melting point data.Ammoniate of high purity possessed hig