• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
Pharmacokinetic Studies of Nevin Fibrinolytic Enzyme[J]. Journal of China Pharmaceutical University, 1997, (2): 107-110.
Citation: Pharmacokinetic Studies of Nevin Fibrinolytic Enzyme[J]. Journal of China Pharmaceutical University, 1997, (2): 107-110.
shu

Pharmacokinetic Studies of Nevin Fibrinolytic Enzyme

More Information
    Graphical Abstract
    • Abstract
  • The pharmacokinetics of nevin fibrinolytic enzyme (NFE) was studied by 125I-NFE as a tracer. Experiment results have showed that the time-concentration curve mainly was fitted to a two-compartment model after i.v , and its T1/2β were 6.1h(0.02u/kg),6.3h(0.04u/kg)and 5.6h(0.08u/kg) respectively. The 125I-NFE was found to be distributed w idely in organs of mice after iv , the peak concentration of 125I-NFE in organs appeared at 3h , and its values were as follows: 1.34%(kidney) , 1.09%(lung) , 0.90%(liver) , 0.90%(spleen) , 0.51%(heart) , 0.45%(muscle) and 0.29%(brain). The 85.6% of 125I-NFE was excreted in urine and only 5.4% in feces in 72h after iv. The percentage of gall excretion in rats was 12 in 8h after iv.
    • FullText(HTML)
    • References (0)
    • Related Articles

  • Related Articles

    [1]CHEN Xi, JIN Liang. Research progress on sumoylation in type 2 diabetes mellitus[J]. Journal of China Pharmaceutical University, 2025, 56(1): 125-131. DOI: 10.11665/j.issn.1000-5048.2023112002
    [2]MU Jinming, LIU Yue, ZHANG Fangfang, JIN Liang. Relationship between circular RNA and type 2 diabetes and its clinical application[J]. Journal of China Pharmaceutical University, 2020, 51(3): 374-378. DOI: 10.11665/j.issn.1000-5048.20200316
    [3]DU Te, CHEN Jing, SHEN Xu. Research advances in susceptibility genes of non-alcoholic fatty liver disease and its association with type 2 diabetes[J]. Journal of China Pharmaceutical University, 2018, 49(5): 537-544. DOI: 10.11665/j.issn.1000-5048.20180504
    [4]HE Dongmei, YOU Qi, WU Jie. Application of microbial vaccines in type 1 diabetes mellitus[J]. Journal of China Pharmaceutical University, 2018, 49(2): 158-164. DOI: 10.11665/j.issn.1000-5048.20180204
    [5]CAO Lanjie, ZHU Kuiniu, JIANG Cuihua, GUNN ·Jordan, CHE Chun-Tao, ZHANG Jian, YIN Zhiqi. Intervention effects of the extract of Alismatis Rhizoma on streptozotocin-induced type 2 diabetic rats[J]. Journal of China Pharmaceutical University, 2017, 48(5): 601-608. DOI: 10.11665/j.issn.1000-5048.20170516
    [6]WANG Xinning, XU Bin, ZHOU Jinpei, ZHANG Huibin. Advances of anti-diabetic drugs based on new targets[J]. Journal of China Pharmaceutical University, 2015, 46(2): 141-152. DOI: 10.11665/j.issn.1000-5048.20150202
    [7]LU Shiping, JIN Liang, WU Jie. Clinical development of type 1 diabetes vaccine[J]. Journal of China Pharmaceutical University, 2014, 45(6): 625-632. DOI: 10.11665/j.issn.1000-5048.20140603
    [8]WU Jie, LIU Xiaorui, YANG Xue, HOU Jing, XU Maolei, SHEN Lili, HUANG Dongcheng, LIU Kunfeng. Hypoglycemic effect of Lactococcus lactis vaccine containing HSP65-6P277 on streptozotocin-induced type 1 diabetic mice[J]. Journal of China Pharmaceutical University, 2014, 45(1): 106-110. DOI: 10.11665/j.issn.1000-5048.20140120
    [9]LI Chen, YUAN Linhua, MA Xueqin, LIU Xiaoquan, XI Tao. Variation of cardiovascular risk biomarkers in type 2 diabetes mellitus[J]. Journal of China Pharmaceutical University, 2013, 44(3): 257-262. DOI: 10.11665/j.issn.1000-5048.20130314
    [10]Determination of the Concentration of Intracellular Calcium in Lymphocyte by Fluo 3 AM and Study of the Influence of the Drugs on Calcium Release[J]. Journal of China Pharmaceutical University, 1999, (6): 53-57.

Catalog

    Get Citation
    PDF
    XML
    Article views (1082) PDF downloads (711) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：331183

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return