Improved synthesis of 2，5-anhydro-3，4，6-tri-O-benzyl-D-glucitol

Aim ：To improve the synthesis for 2，5-anhydro-3，4，6-tri-O-benzyl-D-glucitol. Methods ：Dehydration of D-mannitol，followed by a reaction sequence of selective protection，benzylation，deprotection，tritylation，benzylation and removal of the trityl group，afforded the title compound. Results ：Based on the improvement of the reported synthetic route，2，5-anhydro-3，4，6-tri-O-benzyl-D-glucitol was synthesized in seven steps from D-mannitol with a total yield of 8.3%. Conclusion ：This new method features mild reaction conditions and facile work-up.