Antitumor activities of chemical constituents of Cephalotaxus fortunei in Guizhou province

To study the antitumor activities of the constituents of Cephalotaxus fortunei distributed in Guizhou province. Methods ：The constituents were isolated by column chromatography and identified by physical and spectral analysis.Meanwhile，the anti-tumor activities of some compounds were evaluated by sulforhodamine B(SRB) and MTT assay. Results ：Eleven compounds were isolated and identified as apigenin (I)，β-sitosterol (II)，acetylcephalotaxine (III)，chrysoeriol (IV)，drupacine (V)，1-hentriacontanol (VI)，7，3′，4′-trihydroxyflavone (VII)，sugiol (VIII)，cephalotaxine (IX)，wllsonine (X)，and hainanolide (XI)，respectively.Biological screening Results demonstrated that some of the tested compounds exhibited the antitumor activities in vitro. Conclusion ：Compounds II，VI-VIII were isolated from this plant for the first time.Compound XI has a better inhibitory activity on cell line A549 and K562 .