Synthesis and anti-platelet aggregation activities of ferulic acid esters

Aim ：To study the synthesis and anti-platelet aggregation activities of ferulic acidic esters so as to search for novel antithrombus agents. Methods ：Based on prodrug strategy and combination principles，monoesters were first synthesized by reaction of ferulic acid with alcohols，and then the monoesters were coupled with aspirin to afford bis-esters.The target compounds were assayed for anti-platelet aggregation activities in vitro. Results ：Sixteen target compounds and eight sideproducts including 15 new compounds were synthesized and their structures were determined by IR，MS and ¹H NMR.The results demonstrated that some tested compounds exhibited potential anti-platelet aggregation activities. Conclusion ：The bis-esters of ferulic esters coupling with aspirin with 4 to 5 carbons in side chain might be used as lead compounds for further study in searching for novel antithrombus agents.