• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
Research of anti-tumor peptide neutralizing antibodies activities[J]. Journal of China Pharmaceutical University, 2010, 41(2): 171-174.
Citation: Research of anti-tumor peptide neutralizing antibodies activities[J]. Journal of China Pharmaceutical University, 2010, 41(2): 171-174.

Research of anti-tumor peptide neutralizing antibodies activities

More Information
  • The generation and activity of serum neuralizing antibody in cynomolgus monkeys and SD rats undergoing long-term toxicity study with antitumor peptides HM-3 were investigated.The rats were administered intravenously with HM-3 at doses of 4.5 mg/kg,13.5 mg/kg,and 40.5 mg/kg for 6 months,and the cynomolgus monkeys were administrated intravenously with HM-3 at doses of 3 mg/kg,9 mg/kg and 27 mg/kg for 6 months,respectively.Anti-HM-3 antibodies and their neutralizing activities in serum samples taken every month after the administrations were determined by ELISA and cell migration assay,respectively.During the long-term administrations,anti-HM-3 antibodies were generated in some SD rats at high and moderate dose groups,and the anti-body-neutralizing activities could be detected in a number of these samples (P<0.05).However,activity could be detected in very few monkeys (P<0.05),and the antibody titers were not correlated with the neutralizing activities.Therefore,we conclude that the antigenicity of HM-3 was low,but after long-term administration at high dose,low affinity neutralizing antibody could be generated in small number of samples.

Catalog

    Article views (2184) PDF downloads (3129) Cited by()
    Turn off MathJax
    Article Contents

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return