Advances in the research of anti-tuberculosis drugs

Tuberculosis is increasingly becoming a major health problem worldwide，with approximately 1.8 million people dying annually from the disease.The emergence of drug resistant strains and HIV/TB co-infection has been the major challenge to the treatment of tuberculosis.Thus，it is urgent to develop new potential anti-tuberculosis (anti-TB) drugs.Given the present situation，researchers increasingly focused on the R&D of anti-TB drugs and discovered many active candidates with good potential，some of which have entered clinical trials.This review summarized the structures，mechanism of action，structure-activity relationships，activity and clinical applications of several new class of anti-TB drugs.